PRM/NIR sensor for brain hematoma detection and oxygenation monitoring

Liu Zheng, H. Sang Lee, Sandor Lokos, Jin Kim, Daniel F Hanley, David A. Wilson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The pseudo-random modulation/near infrared sensor (PRM/NIR Sensor) is a low cost portable system designed for time-resolved tissue diagnosis, especially hematoma detection in the emergency care facility. The sensor consists of a personal computer and a hardware unit enclosed in a box of size 37 × 37 × 31 cm3 and of weight less than 10 kg. Two pseudo-random modulated diode lasers emitting at 670 nm and 810 nm are used in the sensor as light sources. The sensor can be operated either in a single wavelength mode or a true differential mode. Optical fiber bundles are used for convenient light delivery and color filters are used to reject room light. Based on a proprietary resolution-enhancement correlation technique, the system achieves a time resolution better than 40 ps with a PRM modulation speed of 200 MHz and a sampling rate of 1-10 Gs/s. Using the prototype sensor, phantom experiments have been conducted to study the feasibility of the sensor. Brain's optical properties are simulated with solutions of intralipid and ink. Hematomas are simulated with bags of paint and hemoglobin immersed in the solution of varies sizes, depths, and orientations. Effects of human skull and hair are studied experimentally. In animal experiment, the sensor was used to monitor the cerebral oxygenation change due to hypercapnia, hypoxia, and hyperventilation. Good correlations were found between NIR measurement parameters and physiological changes induced to the animals.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsT. Vo-Dinh, R.A. Lieberman, G.G. Vurek, A. Katzir
Pages281-290
Number of pages10
Volume2976
DOIs
StatePublished - 1997
Externally publishedYes
EventProceedings of Biomedical Sensing, Imaging and Tracking Technologies II - San Jose, CA, United States
Duration: Feb 11 1997Feb 13 1997

Other

OtherProceedings of Biomedical Sensing, Imaging and Tracking Technologies II
CountryUnited States
CitySan Jose, CA
Period2/11/972/13/97

Fingerprint

Oxygenation
oxygenation
brain
Brain
Monitoring
sensors
Sensors
hyperventilation
animals
hypercapnia
Animals
Modulation
modulation
Wave filters
skull
Hemoglobin
hypoxia
hair
emergencies
bags

Keywords

  • Brain hematoma detection
  • Cerebral oxygenation monitoring
  • Low cost
  • Noninvasive
  • Portable
  • PRM/NIR Sensor

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Zheng, L., Lee, H. S., Lokos, S., Kim, J., Hanley, D. F., & Wilson, D. A. (1997). PRM/NIR sensor for brain hematoma detection and oxygenation monitoring. In T. Vo-Dinh, R. A. Lieberman, G. G. Vurek, & A. Katzir (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2976, pp. 281-290) https://doi.org/10.1117/12.275537

PRM/NIR sensor for brain hematoma detection and oxygenation monitoring. / Zheng, Liu; Lee, H. Sang; Lokos, Sandor; Kim, Jin; Hanley, Daniel F; Wilson, David A.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / T. Vo-Dinh; R.A. Lieberman; G.G. Vurek; A. Katzir. Vol. 2976 1997. p. 281-290.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Zheng, L, Lee, HS, Lokos, S, Kim, J, Hanley, DF & Wilson, DA 1997, PRM/NIR sensor for brain hematoma detection and oxygenation monitoring. in T Vo-Dinh, RA Lieberman, GG Vurek & A Katzir (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 2976, pp. 281-290, Proceedings of Biomedical Sensing, Imaging and Tracking Technologies II, San Jose, CA, United States, 2/11/97. https://doi.org/10.1117/12.275537
Zheng L, Lee HS, Lokos S, Kim J, Hanley DF, Wilson DA. PRM/NIR sensor for brain hematoma detection and oxygenation monitoring. In Vo-Dinh T, Lieberman RA, Vurek GG, Katzir A, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2976. 1997. p. 281-290 https://doi.org/10.1117/12.275537
Zheng, Liu ; Lee, H. Sang ; Lokos, Sandor ; Kim, Jin ; Hanley, Daniel F ; Wilson, David A. / PRM/NIR sensor for brain hematoma detection and oxygenation monitoring. Proceedings of SPIE - The International Society for Optical Engineering. editor / T. Vo-Dinh ; R.A. Lieberman ; G.G. Vurek ; A. Katzir. Vol. 2976 1997. pp. 281-290
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