PRK-induced anisometropia in the rabbit as a model of myopia

Michael R. Bryant, Juergen Kampmeier, Hamdi Er, Ngamjit Kasetsuwan, Daniel Sanchez-DiMartino, Sujal S. Shah, Peter J. McDonnell

Research output: Contribution to journalArticle

Abstract

Background: Current animal models of myopia, such as the chick and the tree shrew, have characteristics that limit their applicability to human myopia and/or their use among researchers. The purpose of this study was to establish a rabbit model of myopia based on photorefractive keratectomy (PRK)-induced anisometropia. Methods: A group of five pigmented rabbits was treated with a monocular -5 D PRK at 5 weeks of age. At 10 weeks of age, two of the eyes were retreated with a second -5 D PRK procedure to compensate for partial regression of the refractive effect. A second group of six pigmented rabbits was treated with a monocular -6 D PRK at 10 weeks of age. Longitudinal measurements of corneal curvature, refraction, and axial length were performed until the rabbits were 13 and 21 weeks of age in groups 1 and 2, respectively. The rabbits in each group were from the same litter. Results: Keratometry and retinoscopy measurements confirmed the refractive effect of the PRK procedures. At the final measurement point in group 1, the PRK-treated eyes were significantly longer than the untreated eyes (16.01 ± 0.45 mm vs 15.45 ± 0.56 mm). In group 2, the PRK-treated eyes were significantly longer by 0.19 mm and 0.20 mm at ages 19 and 21 weeks, respectively. Conclusions: PRK-induced anisometropia is an effective technique to induce hyperopic error compensation in the rabbit as a model of myopic development. The technique is effective if the PRK procedure is performed at either 5 or 10 weeks of age. However, after PRK at 5 weeks of age, partial retreatment may be necessary due to regression of the PRK effect.

Original languageEnglish (US)
Pages (from-to)161-165
Number of pages5
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume237
Issue number2
DOIs
StatePublished - Feb 1999

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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    Bryant, M. R., Kampmeier, J., Er, H., Kasetsuwan, N., Sanchez-DiMartino, D., Shah, S. S., & McDonnell, P. J. (1999). PRK-induced anisometropia in the rabbit as a model of myopia. Graefe's Archive for Clinical and Experimental Ophthalmology, 237(2), 161-165. https://doi.org/10.1007/s004170050212