Abstract
Plasma 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and 25-hydroxyvitamin D (250HD) concentrations were measured in twenty patients with metabolic bone disease due either to privational causes (10 patients) or malabsorption (10 patients). Abnormally low plasma 1,25(OH)2D3 levels were found in eleven patients, six with privational and five with malabsorption bone disease. Normal plasma 1,25(OH)2D3 concentrations were found in the remaining nine patients; of these, five were either receiving anticonvulsant therapy or had been hospitalised prior to investigation. In the absence of either of these factors, normal plasma 1,25(OH)2D3 levels were only found in patients with malabsorptionassociated bone disease. Plasma 250HD levels were below normal in eleven patients; six had malabsorption and five had privational bone disease. In the fifteen patients not receiving anticonvulsants there were significant inverse correlations between plasma 1,25(OH)2D3 levels and the osteoid volume, surface and seam thickness index. This study indicates that plasma 1,25(OH)2D3 concentrations are low in privational osteomalacia in the absence of anticonvulsant therapy or hospitalisation, although normal levels may occur in malabsorption metabolic bone disease uncomplicated by these factors. The plasma 1,25(OH)2D3 concentration appears to be inversely related to the histological severity of bone disease in patients not receiving anticonvulsant therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 165-170 |
| Number of pages | 6 |
| Journal | Metabolic Bone Disease and Related Research |
| Volume | 3 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1981 |
| Externally published | Yes |
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Keywords
- Malabsorption
- Metabolic Bone Disease
- Osteomalacia
- Plasma 1,25-dihydroxyvitamin D
- Plasma 25-hydroxyvitamin D
- Quantitative Bone Histology
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Surgery
Cite this
Privational and malabsorption metabolic bone disease : Plasma vitamin D metabolite concentrations and their relationship to quantitative bone histology. / Compston, J. E.; Vedi, S.; Merrett, A. L.; Clemens, Thomas; O'Riordan, J. L H; Woodhead, J. S.
In: Metabolic Bone Disease and Related Research, Vol. 3, No. 3, 1981, p. 165-170.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Privational and malabsorption metabolic bone disease
T2 - Plasma vitamin D metabolite concentrations and their relationship to quantitative bone histology
AU - Compston, J. E.
AU - Vedi, S.
AU - Merrett, A. L.
AU - Clemens, Thomas
AU - O'Riordan, J. L H
AU - Woodhead, J. S.
PY - 1981
Y1 - 1981
N2 - Plasma 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and 25-hydroxyvitamin D (250HD) concentrations were measured in twenty patients with metabolic bone disease due either to privational causes (10 patients) or malabsorption (10 patients). Abnormally low plasma 1,25(OH)2D3 levels were found in eleven patients, six with privational and five with malabsorption bone disease. Normal plasma 1,25(OH)2D3 concentrations were found in the remaining nine patients; of these, five were either receiving anticonvulsant therapy or had been hospitalised prior to investigation. In the absence of either of these factors, normal plasma 1,25(OH)2D3 levels were only found in patients with malabsorptionassociated bone disease. Plasma 250HD levels were below normal in eleven patients; six had malabsorption and five had privational bone disease. In the fifteen patients not receiving anticonvulsants there were significant inverse correlations between plasma 1,25(OH)2D3 levels and the osteoid volume, surface and seam thickness index. This study indicates that plasma 1,25(OH)2D3 concentrations are low in privational osteomalacia in the absence of anticonvulsant therapy or hospitalisation, although normal levels may occur in malabsorption metabolic bone disease uncomplicated by these factors. The plasma 1,25(OH)2D3 concentration appears to be inversely related to the histological severity of bone disease in patients not receiving anticonvulsant therapy.
AB - Plasma 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and 25-hydroxyvitamin D (250HD) concentrations were measured in twenty patients with metabolic bone disease due either to privational causes (10 patients) or malabsorption (10 patients). Abnormally low plasma 1,25(OH)2D3 levels were found in eleven patients, six with privational and five with malabsorption bone disease. Normal plasma 1,25(OH)2D3 concentrations were found in the remaining nine patients; of these, five were either receiving anticonvulsant therapy or had been hospitalised prior to investigation. In the absence of either of these factors, normal plasma 1,25(OH)2D3 levels were only found in patients with malabsorptionassociated bone disease. Plasma 250HD levels were below normal in eleven patients; six had malabsorption and five had privational bone disease. In the fifteen patients not receiving anticonvulsants there were significant inverse correlations between plasma 1,25(OH)2D3 levels and the osteoid volume, surface and seam thickness index. This study indicates that plasma 1,25(OH)2D3 concentrations are low in privational osteomalacia in the absence of anticonvulsant therapy or hospitalisation, although normal levels may occur in malabsorption metabolic bone disease uncomplicated by these factors. The plasma 1,25(OH)2D3 concentration appears to be inversely related to the histological severity of bone disease in patients not receiving anticonvulsant therapy.
KW - Malabsorption
KW - Metabolic Bone Disease
KW - Osteomalacia
KW - Plasma 1,25-dihydroxyvitamin D
KW - Plasma 25-hydroxyvitamin D
KW - Quantitative Bone Histology
UR - http://www.scopus.com/inward/record.url?scp=0019749699&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019749699&partnerID=8YFLogxK
U2 - 10.1016/0221-8747(81)90003-5
DO - 10.1016/0221-8747(81)90003-5
M3 - Article
C2 - 6897097
AN - SCOPUS:0019749699
VL - 3
SP - 165
EP - 170
JO - Bone
JF - Bone
SN - 8756-3282
IS - 3
ER -