Prioritizing surveillance of Nipah virus in India

Raina K. Plowright, Daniel J. Becker, Daniel E. Crowley, Alex D. Washburne, Tao Huang, P. O. Nameer, Emily Gurley, Barbara A. Han

Research output: Contribution to journalArticle

Abstract

The 2018 outbreak of Nipah virus in Kerala, India, highlights the need for global surveillance of henipaviruses in bats, which are the reservoir hosts for this and other viruses. Nipah virus, an emerging paramyxovirus in the genus Henipavirus, causes severe disease and stuttering chains of transmission in humans and is considered a potential pandemic threat. In May 2018, an outbreak of Nipah virus began in Kerala, > 1800 km from the sites of previous outbreaks in eastern India in 2001 and 2007. Twenty-three people were infected and 21 people died (16 deaths and 18 cases were laboratory confirmed). Initial surveillance focused on insectivorous bats (Megaderma spasma), whereas follow-up surveys within Kerala found evidence of Nipah virus in fruit bats (Pteropus medius). P. medius is the confirmed host in Bangladesh and is now a confirmed host in India. However, other bat species may also serve as reservoir hosts of henipaviruses. To inform surveillance of Nipah virus in bats, we reviewed and analyzed the published records of Nipah virus surveillance globally. We applied a trait-based machine learning approach to a subset of species that occur in Asia, Australia, and Oceana. In addition to seven species in Kerala that were previously identified as Nipah virus seropositive, we identified at least four bat species that, on the basis of trait similarity with known Nipah virus-seropositive species, have a relatively high likelihood of exposure to Nipah or Nipah-like viruses in India. These machine-learning approaches provide the first step in the sequence of studies required to assess the risk of Nipah virus spillover in India. Nipah virus surveillance not only within Kerala but also elsewhere in India would benefit from a research pipeline that included surveys of known and predicted reservoirs for serological evidence of past infection with Nipah virus (or cross reacting henipaviruses). Serosurveys should then be followed by longitudinal spatial and temporal studies to detect shedding and isolate virus from species with evidence of infection. Ecological studies will then be required to understand the dynamics governing prevalence and shedding in bats and the contacts that could pose a risk to public health.

Original languageEnglish (US)
Pages (from-to)e0007393
JournalPLoS neglected tropical diseases
Volume13
Issue number6
DOIs
StatePublished - Jun 1 2019

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Nipah Virus
India
Henipavirus
Disease Outbreaks
Virus Shedding
Stuttering
Time and Motion Studies
Bangladesh
Pandemics
Infection

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Plowright, R. K., Becker, D. J., Crowley, D. E., Washburne, A. D., Huang, T., Nameer, P. O., ... Han, B. A. (2019). Prioritizing surveillance of Nipah virus in India. PLoS neglected tropical diseases, 13(6), e0007393. https://doi.org/10.1371/journal.pntd.0007393

Prioritizing surveillance of Nipah virus in India. / Plowright, Raina K.; Becker, Daniel J.; Crowley, Daniel E.; Washburne, Alex D.; Huang, Tao; Nameer, P. O.; Gurley, Emily; Han, Barbara A.

In: PLoS neglected tropical diseases, Vol. 13, No. 6, 01.06.2019, p. e0007393.

Research output: Contribution to journalArticle

Plowright, RK, Becker, DJ, Crowley, DE, Washburne, AD, Huang, T, Nameer, PO, Gurley, E & Han, BA 2019, 'Prioritizing surveillance of Nipah virus in India', PLoS neglected tropical diseases, vol. 13, no. 6, pp. e0007393. https://doi.org/10.1371/journal.pntd.0007393
Plowright RK, Becker DJ, Crowley DE, Washburne AD, Huang T, Nameer PO et al. Prioritizing surveillance of Nipah virus in India. PLoS neglected tropical diseases. 2019 Jun 1;13(6):e0007393. https://doi.org/10.1371/journal.pntd.0007393
Plowright, Raina K. ; Becker, Daniel J. ; Crowley, Daniel E. ; Washburne, Alex D. ; Huang, Tao ; Nameer, P. O. ; Gurley, Emily ; Han, Barbara A. / Prioritizing surveillance of Nipah virus in India. In: PLoS neglected tropical diseases. 2019 ; Vol. 13, No. 6. pp. e0007393.
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