Principles of Immunotherapy in Non-Small Cell Lung Cancer

Melinda L. Hsu, Jarushka Naidoo

Research output: Contribution to journalReview article

Abstract

Immunotherapy has transformed the treatment of many tumors. Robust data demonstrating improved overall survival and progression-free survival in patients treated with monoclonal antibodies have established immune checkpoint inhibitors as standard of care in stages III and IV non-small cell lung cancer. Nivolumab is effective in previously treated patients with metastatic non-small cell lung cancer. Pembrolizumab and atezolizumab are approved as monotherapy and in combination with other therapies. Ongoing trials investigate the potential role of immunotherapy in earlier disease settings. Identifying predictive biomarkers of response will further amplify the impact of immune checkpoint inhibitors in the treatment of non-small cell lung cancer.

Original languageEnglish (US)
Pages (from-to)187-198
Number of pages12
JournalThoracic surgery clinics
Volume30
Issue number2
DOIs
StatePublished - May 1 2020

Keywords

  • Anti-PD-1
  • Anti-PD-L1
  • Immune checkpoint inhibitors
  • Immunotherapy
  • Non-small cell lung cancer

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine

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