Primus inter pares (First among equals)

J. L. Keck, J. M. Berger

Research output: Contribution to journalShort surveypeer-review


Priming of DNA replication in eukaryotes is carried out by a heterotetrameric complex known as pol α-primase. The structure of the Pyrococcus furiosus RNA polymerase subunit of this complex shows that priming is carried out by unrelated proteins in archaea/eukarya and eubacteria, provides insights into the mechanism of action of a novel RNA polymerase, and raises new questions regarding the ancestry of priming and replication in the three domains of life.

Original languageEnglish (US)
Pages (from-to)2-4
Number of pages3
JournalNature structural biology
Issue number1
StatePublished - Jan 19 2001
Externally publishedYes

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Genetics

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