Abstract
Priming of DNA replication in eukaryotes is carried out by a heterotetrameric complex known as pol α-primase. The structure of the Pyrococcus furiosus RNA polymerase subunit of this complex shows that priming is carried out by unrelated proteins in archaea/eukarya and eubacteria, provides insights into the mechanism of action of a novel RNA polymerase, and raises new questions regarding the ancestry of priming and replication in the three domains of life.
Original language | English (US) |
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Pages (from-to) | 2-4 |
Number of pages | 3 |
Journal | Nature Structural Biology |
Volume | 8 |
Issue number | 1 |
DOIs | |
State | Published - 2001 |
Externally published | Yes |
ASJC Scopus subject areas
- Structural Biology
- Biochemistry
- Genetics