Primordial germ cells, stem cells and testicular cancer

Peter J. Donovan, Maria De Miguel, Linzhao Cheng, James L. Resnick

Research output: Contribution to journalArticle

Abstract

Primordial Germ Cells (PGCs) arise in the mouse embryo as a small population of cells some way from the gonad anlagen. In order for the embryo to develop into a fully fertile adult animal the PGCs must increase in number and reach the gonad. Mutations causing sterility in the mouse have identified some of the genes involved in regulating PGC development and some of these genes have been molecularly cloned. Similarly, mutations affecting the development and differentiation of PGC-derived tumors (teratomas and teratocarcinomas) have been identified in certain strains of mice and these identify genes involved in the normal growth and differentiation of PGCs. These studies should help to define the role of growth factors in PGC development and in the development of germ-cell-derived tumors.

Original languageEnglish (US)
Pages (from-to)134-141
Number of pages8
JournalAPMIS
Volume106
Issue number1
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

Keywords

  • EG cells
  • Germ cells
  • Lif
  • Teratocarcinoma
  • bFGF
  • c-kit/Steel factor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Immunology and Allergy
  • Microbiology (medical)

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