Priming the pancreatic cancer tumor microenvironment for checkpoint-inhibitor immunotherapy

Eric R. Lutz, Heather Kinkead, Elizabeth M. Jaffee, Lei Zheng

Research output: Contribution to journalArticlepeer-review

Abstract

Single agent immunotherapy is effective against several cancers, but has failed against poorly immunogenic cancers, including pancreatic cancer. Evaluation of pancreatic tumors following treatment with an experimental vaccine (Lutz et al. Cancer Immunology Research 2014) suggests that vaccination primes the tumor microenvironment (TME) for checkpoint-inhibitor immunotherapy, and supports a new platform for evaluating checkpoint-inhibitors in poorly immunogenic cancers.

Original languageEnglish (US)
Pages (from-to)e962401-1-e962401-3
JournalOncoImmunology
Volume3
Issue number11
DOIs
StatePublished - Nov 2 2014

Keywords

  • pancreatic cancer
  • tumor immunotherapy
  • tumor vaccines

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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