Priming of CD8+ T cell responses to liver stage malaria parasite antigens

Giampietro Corradin, Jelena Levitskaya

Research output: Contribution to journalArticle

Abstract

While the role of malaria parasite-specific memory CD8+ T cells in the control of exo-erythrocytic stages of malaria infection is well documented and generally accepted, a debate is still ongoing regarding both the identity of the anatomic site where the activation of naive pathogen-specific T cells is taking place and contribution of different antigen-presenting cells (APCs) into this process. Whereas some studies infer a role of professional APCs present in the lymph nodes draining the site of parasite injection by the mosquito, others argue in favor of the liver as a primary organ and hepatocytes as stimulators of naïve parasite-specific T cell responses. This review aims to critically analyze the current knowledge and outline new lines of research necessary to understand the induction of protective cellular immunity against the malaria parasite.

Original languageEnglish (US)
Article number527
JournalFrontiers in Immunology
Volume5
Issue numberNOV
DOIs
Publication statusPublished - 2014

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Keywords

  • Antigen presentation to T cells
  • Dendritic and liver cells as APC
  • Liver stage antigens
  • Malaria
  • Plasmodium

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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