Abstract
While the role of malaria parasite-specific memory CD8+ T cells in the control of exo-erythrocytic stages of malaria infection is well documented and generally accepted, a debate is still ongoing regarding both the identity of the anatomic site where the activation of naive pathogen-specific T cells is taking place and contribution of different antigen-presenting cells (APCs) into this process. Whereas some studies infer a role of professional APCs present in the lymph nodes draining the site of parasite injection by the mosquito, others argue in favor of the liver as a primary organ and hepatocytes as stimulators of naïve parasite-specific T cell responses. This review aims to critically analyze the current knowledge and outline new lines of research necessary to understand the induction of protective cellular immunity against the malaria parasite.
| Original language | English (US) |
|---|---|
| Article number | 527 |
| Journal | Frontiers in Immunology |
| Volume | 5 |
| Issue number | NOV |
| DOIs | |
| State | Published - 2014 |
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Keywords
- Antigen presentation to T cells
- Dendritic and liver cells as APC
- Liver stage antigens
- Malaria
- Plasmodium
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
Priming of CD8+ T cell responses to liver stage malaria parasite antigens. / Corradin, Giampietro; Levitskaya, Jelena.
In: Frontiers in Immunology, Vol. 5, No. NOV, 527, 2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Priming of CD8+ T cell responses to liver stage malaria parasite antigens
AU - Corradin, Giampietro
AU - Levitskaya, Jelena
PY - 2014
Y1 - 2014
N2 - While the role of malaria parasite-specific memory CD8+ T cells in the control of exo-erythrocytic stages of malaria infection is well documented and generally accepted, a debate is still ongoing regarding both the identity of the anatomic site where the activation of naive pathogen-specific T cells is taking place and contribution of different antigen-presenting cells (APCs) into this process. Whereas some studies infer a role of professional APCs present in the lymph nodes draining the site of parasite injection by the mosquito, others argue in favor of the liver as a primary organ and hepatocytes as stimulators of naïve parasite-specific T cell responses. This review aims to critically analyze the current knowledge and outline new lines of research necessary to understand the induction of protective cellular immunity against the malaria parasite.
AB - While the role of malaria parasite-specific memory CD8+ T cells in the control of exo-erythrocytic stages of malaria infection is well documented and generally accepted, a debate is still ongoing regarding both the identity of the anatomic site where the activation of naive pathogen-specific T cells is taking place and contribution of different antigen-presenting cells (APCs) into this process. Whereas some studies infer a role of professional APCs present in the lymph nodes draining the site of parasite injection by the mosquito, others argue in favor of the liver as a primary organ and hepatocytes as stimulators of naïve parasite-specific T cell responses. This review aims to critically analyze the current knowledge and outline new lines of research necessary to understand the induction of protective cellular immunity against the malaria parasite.
KW - Antigen presentation to T cells
KW - Dendritic and liver cells as APC
KW - Liver stage antigens
KW - Malaria
KW - Plasmodium
UR - http://www.scopus.com/inward/record.url?scp=84919437154&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84919437154&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2014.00527
DO - 10.3389/fimmu.2014.00527
M3 - Article
VL - 5
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
IS - NOV
M1 - 527
ER -