Primate gastric circulation: effects of catecholamines and adrenergic blockade

M. J. Zinner, J. C. Kerr, D. G. Reynolds

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The effects of intra arterial injections and infusions of epinephrine, norepinephrine, and isoproterenol on gastric blood flow were studied in anesthetized baboons. Blood flow was measured electromagnetically before and after adrenergic blockade. The results for injected epinephrine and norepinephrine indicate these agents to be pure vasoconstrictors in the primate gastric circulation, and this response is attenuated by alpha adrenergic blockade with phenoxybenzamine. Isoproterenol is a pure vasodilator, and its response is attenuated following beta adrenergic blockade with propranolol. Intra arterial infusions of epinephrine and norepinephrine (.05 μg kg-1 min-1 resulted in sustained vasoconstriction with no evidence of autoregulatory escape and no postinfusion 'overshoot'. This study suggests that epinephrine and norepinephrine might provide alternatives to vasopressin as a vasoconstrictor for the control of upper gastrointestinal bleeding.

Original languageEnglish (US)
Title of host publicationAmerican Journal of Physiology
Pages346-350
Number of pages5
Volume230
Edition2
StatePublished - 1976
Externally publishedYes

Fingerprint

Adrenergic Agents
Primates
Epinephrine
Catecholamines
Stomach
Norepinephrine
Intra Arterial Infusions
Vasoconstrictor Agents
Isoproterenol
Intra-Arterial Injections
Phenoxybenzamine
Papio
Vasoconstriction
Vasopressins
Vasodilator Agents
Propranolol
Hemorrhage

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Zinner, M. J., Kerr, J. C., & Reynolds, D. G. (1976). Primate gastric circulation: effects of catecholamines and adrenergic blockade. In American Journal of Physiology (2 ed., Vol. 230, pp. 346-350)

Primate gastric circulation : effects of catecholamines and adrenergic blockade. / Zinner, M. J.; Kerr, J. C.; Reynolds, D. G.

American Journal of Physiology. Vol. 230 2. ed. 1976. p. 346-350.

Research output: Chapter in Book/Report/Conference proceedingChapter

Zinner, MJ, Kerr, JC & Reynolds, DG 1976, Primate gastric circulation: effects of catecholamines and adrenergic blockade. in American Journal of Physiology. 2 edn, vol. 230, pp. 346-350.
Zinner MJ, Kerr JC, Reynolds DG. Primate gastric circulation: effects of catecholamines and adrenergic blockade. In American Journal of Physiology. 2 ed. Vol. 230. 1976. p. 346-350
Zinner, M. J. ; Kerr, J. C. ; Reynolds, D. G. / Primate gastric circulation : effects of catecholamines and adrenergic blockade. American Journal of Physiology. Vol. 230 2. ed. 1976. pp. 346-350
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