Primate disrupted-in-schizophrenia-1 (DISC1)

High divergence of a gene for major mental illnesses in recent evolutionary history

Lyuda Bord, Jeff Wheeler, Matthew Paek, Masoumeh Saleh, Ariel Lyons-Warren, Christopher A Ross, Naoya Sawamura, Akira Sawa

Research output: Contribution to journalArticle

Abstract

Here we analyze the species conservation of disrupted-in-schizophrenia-1 (DISC1) gene, a susceptibility gene for schizophrenia. We cloned cDNA of DISC1 and characterized DISC1 protein in monkey brains and compared their features with those in a variety of species, including humans, rodents and lower vertebrates. Sequences of human and monkey DISC1 are very similar for both nucleotides and amino acids, in sharp contrast to those of rodents; this is reminiscent of G72, another gene involved in major mental illnesses. Bioinformatic cross-species comparisons identified a portion of DISC1 sequences in chicken and Caenorhabditis elegans, but failed to find DISC1 in Drosophila. In contrast to sequence differences, the regional expression profile of DISC1 is well conserved between rodents and primates in that levels of DISC1 mRNA and protein are higher in the hippocampus and the cerebral cortex, and much lower in cerebellum in adult brains. The findings of this study may suggest overall patterns of evolution of genes for psychiatric disorders, and thus assist in production of genetically-engineered mice, and the interpretation of the underlying mechanisms of psychiatric conditions.

Original languageEnglish (US)
Pages (from-to)286-293
Number of pages8
JournalNeuroscience Research
Volume56
Issue number3
DOIs
StatePublished - Nov 2006

Fingerprint

Primates
Schizophrenia
History
Genes
Rodentia
Haplorhini
Psychiatry
Caenorhabditis elegans
Brain
Computational Biology
Cerebral Cortex
Cerebellum
Drosophila
Vertebrates
Chickens
Hippocampus
Proteins
Nucleotides
Complementary DNA
Amino Acids

Keywords

  • DISC1
  • Evolution
  • Primates
  • Rodents
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Primate disrupted-in-schizophrenia-1 (DISC1) : High divergence of a gene for major mental illnesses in recent evolutionary history. / Bord, Lyuda; Wheeler, Jeff; Paek, Matthew; Saleh, Masoumeh; Lyons-Warren, Ariel; Ross, Christopher A; Sawamura, Naoya; Sawa, Akira.

In: Neuroscience Research, Vol. 56, No. 3, 11.2006, p. 286-293.

Research output: Contribution to journalArticle

Bord, Lyuda ; Wheeler, Jeff ; Paek, Matthew ; Saleh, Masoumeh ; Lyons-Warren, Ariel ; Ross, Christopher A ; Sawamura, Naoya ; Sawa, Akira. / Primate disrupted-in-schizophrenia-1 (DISC1) : High divergence of a gene for major mental illnesses in recent evolutionary history. In: Neuroscience Research. 2006 ; Vol. 56, No. 3. pp. 286-293.
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