Primary salivary duct carcinoma of the lung, mucin-rich variant

Gregory A. Fishbein, Brandon S. Grimes, Rena R. Xian, Jay M. Lee, Igor Barjaktarevic, Haodong Xu

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Primary salivary gland-type lung cancer is a heterogeneous group of neoplasms arising from the seromucinous glands of the respiratory tract. Histopathologically, they are identical to salivary gland neoplasms of the head and neck. While mucoepidermoid carcinoma and adenoid cystic carcinoma are overwhelmingly the most common subtypes found in the lung, reports of uncommon subtypes can be found in the literature. We report a case of a 73-year-old woman with primary lung salivary duct carcinoma, mucin-rich variant - an exceedingly rare subtype of an already rare malignant salivary-type neoplasm. One case of primary lung salivary duct carcinoma has been reported in the literature; however, the mucin-rich variant has never been described in the lung. Furthermore, the tumor in our case bears a rare BRAF G464V mutation. To our knowledge, this is the first reported case of a BRAF G464V mutation detected in a salivary duct carcinoma or any other salivary-type neoplasm.

Original languageEnglish (US)
Pages (from-to)150-156
Number of pages7
JournalHuman pathology
Issue number1
StatePublished - Jan 1 2016
Externally publishedYes


  • BRAF
  • Lung cancer
  • Non-small cell lung cancer
  • Salivary duct carcinoma
  • Salivary gland tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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