Primary rhabdomyosarcoma of the distal femoral diaphysis: a case report and review of the literature

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Abstract

Primary rhabdomyosarcoma of the bone is an extremely rare condition with few examples reported in the literature. We present the case of a 34-year-old male who presented with a lesion in the distal femur with initial imaging features consistent with Ewing sarcoma. Histologically, the lesion consisted of atypical pleomorphic polygonal rhabdomyoblasts demonstrating focal desmin and myogenin expression. A diagnosis of pleomorphic rhabdomyosarcoma was rendered. Despite systemic treatment and surgery, this patient experienced a rapidly progressive disease course. We believe this is only the second report in the orthopedic literature of a case of primary pleomorphic rhabdomyosarcoma of the bone. The key imaging, pathologic, and clinical findings are discussed.

Original languageEnglish (US)
Pages (from-to)1391-1395
Number of pages5
JournalSkeletal Radiology
Volume45
Issue number10
DOIs
StatePublished - Oct 1 2016

Keywords

  • Adult rhabdomyosarcoma
  • Pleomorphic rhabdomyosarcoma
  • Primary rhabdomyosarcoma of bone

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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