Primary retinal pathology in multiple sclerosis as detected by optical coherence tomography

Shiv Saidha, Stephanie B. Syc, Mohamed A. Ibrahim, Christopher Eckstein, Christina V. Warner, Sheena K. Farrell, Jonathan D. Oakley, Mary K. Durbin, Scott A. Meyer, Laura J. Balcer, Elliot M. Frohman, Jason M. Rosenzweig, Scott Newsome, John N. Ratchford, Quan D. Nguyen, Peter Calabresi

Research output: Contribution to journalArticle


Optical coherence tomography studies in multiple sclerosis have primarily focused on evaluation of the retinal nerve fibre layer. The aetiology of retinal changes in multiple sclerosis is thought to be secondary to optic nerve demyelination. The objective of this study was to use optical coherence tomography to determine if a subset of patients with multiple sclerosis exhibit primary retinal neuronopathy, in the absence of retrograde degeneration of the retinal nerve fibre layer and to ascertain if such patients may have any distinguishing clinical characteristics. We identified 50 patients with multiple sclerosis with predominantly macular thinning (normal retinal nerve fibre-layer thickness with average macular thickness

Original languageEnglish (US)
Pages (from-to)518-533
Number of pages16
Issue number2
StatePublished - Feb 2011



  • multiple sclerosis
  • multiple sclerosis-severity score
  • optical coherence tomography
  • outer nuclear layer
  • retinal segmentation

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Saidha, S., Syc, S. B., Ibrahim, M. A., Eckstein, C., Warner, C. V., Farrell, S. K., Oakley, J. D., Durbin, M. K., Meyer, S. A., Balcer, L. J., Frohman, E. M., Rosenzweig, J. M., Newsome, S., Ratchford, J. N., Nguyen, Q. D., & Calabresi, P. (2011). Primary retinal pathology in multiple sclerosis as detected by optical coherence tomography. Brain, 134(2), 518-533.