Primary renal sclerosing epithelioid fibrosarcoma: Report of 2 cases with EWSR1-CREB3L1 gene fusion

Pedram Argani, Jack R. Lewin, Pamela Edmonds, George J. Netto, Carlos Prieto-Granada, Lei Zhang, Achim A. Jungbluth, Cristina R. Antonescu

Research output: Contribution to journalArticlepeer-review

Abstract

We report the first 2 genetically confirmed cases of primary renal sclerosing epithelioid fibrosarcoma (SEF), occurring in a 17-year-old boy and a 61-year-old woman. In both cases, the tumors demonstrated the typical epithelioid clear cell morphology associated with extensive hyalinizing fibrosis, raising the differential diagnosis of solitary fibrous tumor, metanephric stromal tumor, and the sclerosing variant of clear cell sarcoma of the kidney. Both neoplasms demonstrated diffuse immunoreactivity for MUC4, a highly specific marker for SEF, and both demonstrated evidence of rearrangement of both the EWSR1 and CREB3L1 genes, which have recently been shown to be fused in this entity. Both neoplasms presented with metastatic disease. Primary renal SEF represents yet another translocation-associated sarcoma now shown to arise primarily in the kidney.

Original languageEnglish (US)
Pages (from-to)365-373
Number of pages9
JournalAmerican Journal of Surgical Pathology
Volume39
Issue number3
DOIs
StatePublished - Feb 28 2015

Keywords

  • fibrosarcoma
  • renal neoplasm
  • translocation

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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