Primary Prevention of Atherosclerotic Cardiovascular Disease in Women

Rebeccah A. McKibben, Mahmoud Al Rifai, Lena M. Mathews, Erin D. Michos

Research output: Contribution to journalReview articlepeer-review


Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and mortality among women. Despite improvements in cardiovascular disease prevention efforts, there remain gaps in cardiovascular disease awareness among women, as well as age and racial disparities in ASCVD outcomes for women. Disparity also exists in the impact the traditional risk factors confer on ASCVD risk between women and men, with smoking and diabetes both resulting in stronger relative risks in women compared to men. Additionally there are risk factors that are unique to women (such as pregnancy-related factors) or that disproportionately affect women (such as auto-immune disease) where preventive efforts should be targeted. Risk assessment and management must also be sex-specific to effectively reduce cardiovascular disease and improve outcomes among women. Evidence supports the use of statin therapy for primary prevention in women at higher ASCVD risk. However, some pause should be given before prescribing aspirin therapy in women without known ASCVD, with most evidence supporting the use of aspirin for women ≥65 years not at increased risk for bleeding. This review article will summarize (1) traditional and non-traditional assessments of ASCVD risk and (2) lifestyle and pharmacologic therapies for the primary prevention of ASCVD in women.

Original languageEnglish (US)
Article number1
Pages (from-to)1-11
Number of pages11
JournalCurrent Cardiovascular Risk Reports
Issue number1
StatePublished - Jan 1 2016


  • Cardiovascular disease
  • Prevention
  • Risk
  • Women

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Primary Prevention of Atherosclerotic Cardiovascular Disease in Women'. Together they form a unique fingerprint.

Cite this