Primary melanocytic neoplasms of the central nervous system

Daniel J. Brat, Caterina Giannini, Bernd W. Scheithauer, Peter C. Burger

Research output: Contribution to journalArticle

Abstract

Primary melanocytic neoplasms of the central nervous system (CNS) consist of a spectrum ranging from well-differentiated melanocytoma to its overtly malignant counterpart, melanoma. Diagnostically difficult intermediate lesions lie between these extremes. Clinicopathologic features of 33 cases were studied to define histologic appearances, diagnostic criteria, and the clinical behavior of lesions along this spectrum. Seventeen cases were well-differentiated, solitary leptomeningeal tumors classified as melanocytomas. They contained variably pigmented melanocytic cells arranged in tight nests, sheets, or fascicles. Mitotic rates ranged from zero to one per 10 high-power fields (HPFs), with most having zero per 10 HPFs. All tumors were immunoreactive for HMB-45 and S-100 protein and negative for epithelial membrane antigen. MIB-1 staining was low (

Original languageEnglish (US)
Pages (from-to)745-754
Number of pages10
JournalAmerican Journal of Surgical Pathology
Volume23
Issue number7
DOIs
StatePublished - Jul 1999

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Central Nervous System Neoplasms
Mucin-1
S100 Proteins
Melanoma
Neoplasms
Staining and Labeling

Keywords

  • Brain tumor
  • Melanocytoma
  • Melanoma

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Primary melanocytic neoplasms of the central nervous system. / Brat, Daniel J.; Giannini, Caterina; Scheithauer, Bernd W.; Burger, Peter C.

In: American Journal of Surgical Pathology, Vol. 23, No. 7, 07.1999, p. 745-754.

Research output: Contribution to journalArticle

Brat, Daniel J. ; Giannini, Caterina ; Scheithauer, Bernd W. ; Burger, Peter C. / Primary melanocytic neoplasms of the central nervous system. In: American Journal of Surgical Pathology. 1999 ; Vol. 23, No. 7. pp. 745-754.
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