Primary management of operable breast cancer by minimal surgery and radiotherapy

S. Alpert, N. A. Ghossein, P. Stacey, F. A. Migliorelli, G. Efron, V. Krishnaswamy

Research output: Contribution to journalArticlepeer-review


109 cases of breast cancer were treated by tumorectomy and radiotherapy or radiotherapy alone. Almost 30% with small tumors (T1, T2) were considered inoperable for medical reasons and 70% refused mastectomy. Over the past five years the number of patients refusing mastectomy has definitely increased. 49 cases of surgically resectable cancers (T1, T2, T3, NO, N1) had a minimum followup of two years (average 4 years ± 3 months). Absolute and determinate survivals NED were 65% and 86%. There were four local recurrences (8%). Secondary mastectomy could be performed on three. Microscopic involvement of the surgical margin by cancer did not alter the local control rate. The cosmetic results were good in 98%. Gross removal of the tumor followed by radiotherapy may be offered as an alternative to mastectomy in patients with operable breast cancer. Cancer 42:2054–2058, 1978.

Original languageEnglish (US)
Pages (from-to)2054-2058
Number of pages5
Issue number4
StatePublished - Oct 1978
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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