TY - JOUR
T1 - Primary Head and Neck Cancer
T2 - Histopathologic Predictors of Recurrence After Neck Dissection in Patients With Lymph Node Involvement
AU - Olsen, Kerry D.
AU - Caruso, Michela
AU - Foote, Robert L.
AU - Stanley, Robert J.
AU - Lewis, Jean E.
AU - Buskirk, Steven J.
AU - Frassica, Deborah A.
AU - Desanto, Lawrence W.
AU - O'fallon, W. Michael
AU - Hoverman, Verna R.
PY - 1994/12
Y1 - 1994/12
N2 - Objective: Retrospectively analyze several histopathologic variables that may predict neck recurrence after neck dissection. Design: From 1970 through 1980, 284 patients with pathologically confirmed metastatic squamous cell carcinoma underwent neck dissection and received no adjuvant therapy. Kaplan-Meier evaluation estimated a 74% 2-year neck recurrence–free rate. After adjusting for the standard covariates of age, gender, neck stage, and tumor grade, we also controlled for the time-dependent co-variates of primary recurrence, occurrence in the side of the neck not operated on, or development of new head and neck primary disease. Setting: A large referral-based practice. Results: The number of lymph nodes involved, invasion of vascular/lymphatic space, invasion of soft tissue, and desmoplastic lymph node pattern adversely affect neck recurrence. A desmoplastic stromal pattern was associated with almost a sevenfold increased risk of neck recurrence. To our knowledge, this finding has not been reported previously. Conclusion: Histopathologic evaluation of metastatically involved cervical nodes can identify patients with head and neck cancer who are at high risk for recurrence.
AB - Objective: Retrospectively analyze several histopathologic variables that may predict neck recurrence after neck dissection. Design: From 1970 through 1980, 284 patients with pathologically confirmed metastatic squamous cell carcinoma underwent neck dissection and received no adjuvant therapy. Kaplan-Meier evaluation estimated a 74% 2-year neck recurrence–free rate. After adjusting for the standard covariates of age, gender, neck stage, and tumor grade, we also controlled for the time-dependent co-variates of primary recurrence, occurrence in the side of the neck not operated on, or development of new head and neck primary disease. Setting: A large referral-based practice. Results: The number of lymph nodes involved, invasion of vascular/lymphatic space, invasion of soft tissue, and desmoplastic lymph node pattern adversely affect neck recurrence. A desmoplastic stromal pattern was associated with almost a sevenfold increased risk of neck recurrence. To our knowledge, this finding has not been reported previously. Conclusion: Histopathologic evaluation of metastatically involved cervical nodes can identify patients with head and neck cancer who are at high risk for recurrence.
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U2 - 10.1001/archotol.1994.01880360066012
DO - 10.1001/archotol.1994.01880360066012
M3 - Article
C2 - 7980903
AN - SCOPUS:0028143299
SN - 0886-4470
VL - 120
SP - 1370
EP - 1374
JO - Archives of Otolaryngology--Head and Neck Surgery
JF - Archives of Otolaryngology--Head and Neck Surgery
IS - 12
ER -