Primary excision compared with re-excision of extremity soft tissue sarcomas-is anything new?

Vignesh K. Alamanda, Samuel N. Crosby, Kristin R. Archer, Yanna Song, Herbert S. Schwartz, Ginger E. Holt

Research output: Contribution to journalArticlepeer-review


Background Soft tissue sarcomas (STS) are rare and are commonly excised outside of a sarcoma center without appropriate preoperative planning. Studies have shown varying results in survival and outcome when comparing patients undergoing re-excision to patients undergoing a single, planned excision. Methods This retrospective study evaluated 278 patients treated for STS of the extremities between January 2000 and July 2006. One hundred seventy-two patients had a primary excision while 106 patients had a sarcoma re-excised. Survival curves for disease-free survival, metastasis-free survival, and local recurrence-free survival were calculated using competing risk analysis for both groups. Results After adjusting for high-risk variables, our results indicate that re-excision is a proxy for smaller, low-grade tumors which tend to have a better survival profile. Death due to sarcoma and distant metastases were correlated with high-grade and large tumors. The presence of positive microscopic margins was the strongest predictor of local recurrence (P

Original languageEnglish (US)
Pages (from-to)662-667
Number of pages6
JournalJournal of Surgical Oncology
Issue number7
StatePublished - Jun 1 2012
Externally publishedYes


  • local recurrence
  • metastasis
  • planned excision
  • re-excision
  • soft tissue sarcoma
  • survival

ASJC Scopus subject areas

  • Surgery
  • Oncology


Dive into the research topics of 'Primary excision compared with re-excision of extremity soft tissue sarcomas-is anything new?'. Together they form a unique fingerprint.

Cite this