Primary Epstein-Barr virus - Associated Hodgkin disease of the ileum complicating Crohn disease

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Abstract

We describe a case of primary Hodgkin disease of the terminal ileum in a 38-year-old man with Crohn disease of 24 years' duration. The infiltrate was located in an ulcerated fistula involving the terminal ileum and urinary bladder. Reed-Sternberg cells and their variants were characteristically positive for CD15, fascin, and CD30 and showed focal positivity for CD20. Epstein-Barr virus messenger RNA was also detected in the neoplastic cells. Staging revealed no evidence of other lymph node or organ involvement. Although rare, primary gastrointestinal Hodgkin disease arising in the setting of Croton disease may have a stronger association with Epstein-Barr virus infection than conventional Hodgkin disease.

Original languageEnglish (US)
Pages (from-to)424-427
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume125
Issue number3
StatePublished - Mar 22 2001

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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