Primary dapsone resistance in Bamako and Chingleput: final report; THELEP

M. Christain; M. J. Colston; G. A. Ellard; C. A.P. Ferracci; J. H. Grosset; G. Grossetete; C. G.S. Iyer; J. Baohong; K. Lwin; D. L. Leiker; L. Levy; S. K. Noordeen; S. R. Pattyn; J. M.H. Pearson; R. J.W. Rees; H. Sansarricq; P. S. Seshadri; J. K. Seydel; C. C. Shepard; M. F.R. Waters

Primary dapsone resistance in Bamako and Chingleput: final report; THELEP

M. Christain, M. J. Colston, G. A. Ellard, C. A.P. Ferracci, J. H. Grosset, G. Grossetete, C. G.S. Iyer, J. Baohong, K. Lwin, D. L. Leiker, L. Levy, S. K. Noordeen, S. R. Pattyn, J. M.H. Pearson, R. J.W. Rees, H. Sansarricq, P. S. Seshadri, J. K. Seydel, C. C. Shepard, M. F.R. Waters

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Approximately 37% of the 131 patients with lepromatous leprosy admitted into the THELEP controlled clinical trials in Bamako and Chingleput, whose Myobacterium leprae obtained from pretreatment biopsy specimens could be tested in mice, have been found to harbour dapsone-resistant organisms, and are though to represent instances of primary resistance to dapsone. The majority of these patients harboured strains of a low degree of resistance, one-fifth of these patients harboured organisms of an intermediated resistance, and no patient was found to harbour M. leprae of a high degree of resistance. No relationships were discerned between patient age, number of M. leprae, or disease classification on one hand, and primary resistance to dapsone on the other.

Original language	English (US)
Pages (from-to)	209-218
Number of pages	10
Journal	Leprosy review
Volume	58
Issue number	3
State	Published - 1987
Externally published	Yes

ASJC Scopus subject areas

Dermatology
Infectious Diseases

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Christain, M., Colston, M. J., Ellard, G. A., Ferracci, C. A. P., Grosset, J. H., Grossetete, G., Iyer, C. G. S., Baohong, J., Lwin, K., Leiker, D. L., Levy, L., Noordeen, S. K., Pattyn, S. R., Pearson, J. M. H., Rees, R. J. W., Sansarricq, H., Seshadri, P. S., Seydel, J. K., Shepard, C. C., & Waters, M. F. R. (1987). Primary dapsone resistance in Bamako and Chingleput: final report; THELEP. Leprosy review, 58(3), 209-218.

Christain, M, Colston, MJ, Ellard, GA, Ferracci, CAP, Grosset, JH, Grossetete, G, Iyer, CGS, Baohong, J, Lwin, K, Leiker, DL, Levy, L, Noordeen, SK, Pattyn, SR, Pearson, JMH, Rees, RJW, Sansarricq, H, Seshadri, PS, Seydel, JK, Shepard, CC & Waters, MFR 1987, 'Primary dapsone resistance in Bamako and Chingleput: final report; THELEP', Leprosy review, vol. 58, no. 3, pp. 209-218.

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title = "Primary dapsone resistance in Bamako and Chingleput: final report; THELEP",

abstract = "Approximately 37% of the 131 patients with lepromatous leprosy admitted into the THELEP controlled clinical trials in Bamako and Chingleput, whose Myobacterium leprae obtained from pretreatment biopsy specimens could be tested in mice, have been found to harbour dapsone-resistant organisms, and are though to represent instances of primary resistance to dapsone. The majority of these patients harboured strains of a low degree of resistance, one-fifth of these patients harboured organisms of an intermediated resistance, and no patient was found to harbour M. leprae of a high degree of resistance. No relationships were discerned between patient age, number of M. leprae, or disease classification on one hand, and primary resistance to dapsone on the other.",

author = "M. Christain and Colston, {M. J.} and Ellard, {G. A.} and Ferracci, {C. A.P.} and Grosset, {J. H.} and G. Grossetete and Iyer, {C. G.S.} and J. Baohong and K. Lwin and Leiker, {D. L.} and L. Levy and Noordeen, {S. K.} and Pattyn, {S. R.} and Pearson, {J. M.H.} and Rees, {R. J.W.} and H. Sansarricq and Seshadri, {P. S.} and Seydel, {J. K.} and Shepard, {C. C.} and Waters, {M. F.R.}",

year = "1987",

language = "English (US)",

volume = "58",

pages = "209--218",

journal = "Leprosy review",

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T1 - Primary dapsone resistance in Bamako and Chingleput

T2 - final report; THELEP

AU - Christain, M.

AU - Colston, M. J.

AU - Ellard, G. A.

AU - Ferracci, C. A.P.

AU - Grosset, J. H.

AU - Grossetete, G.

AU - Iyer, C. G.S.

AU - Baohong, J.

AU - Lwin, K.

AU - Leiker, D. L.

AU - Levy, L.

AU - Noordeen, S. K.

AU - Pattyn, S. R.

AU - Pearson, J. M.H.

AU - Rees, R. J.W.

AU - Sansarricq, H.

AU - Seshadri, P. S.

AU - Seydel, J. K.

AU - Shepard, C. C.

AU - Waters, M. F.R.

PY - 1987

Y1 - 1987

N2 - Approximately 37% of the 131 patients with lepromatous leprosy admitted into the THELEP controlled clinical trials in Bamako and Chingleput, whose Myobacterium leprae obtained from pretreatment biopsy specimens could be tested in mice, have been found to harbour dapsone-resistant organisms, and are though to represent instances of primary resistance to dapsone. The majority of these patients harboured strains of a low degree of resistance, one-fifth of these patients harboured organisms of an intermediated resistance, and no patient was found to harbour M. leprae of a high degree of resistance. No relationships were discerned between patient age, number of M. leprae, or disease classification on one hand, and primary resistance to dapsone on the other.

AB - Approximately 37% of the 131 patients with lepromatous leprosy admitted into the THELEP controlled clinical trials in Bamako and Chingleput, whose Myobacterium leprae obtained from pretreatment biopsy specimens could be tested in mice, have been found to harbour dapsone-resistant organisms, and are though to represent instances of primary resistance to dapsone. The majority of these patients harboured strains of a low degree of resistance, one-fifth of these patients harboured organisms of an intermediated resistance, and no patient was found to harbour M. leprae of a high degree of resistance. No relationships were discerned between patient age, number of M. leprae, or disease classification on one hand, and primary resistance to dapsone on the other.

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C2 - 3312895

AN - SCOPUS:0023552162

SN - 0305-7518

VL - 58

SP - 209

EP - 218

JO - Leprosy review

JF - Leprosy review

IS - 3

ER -

Primary dapsone resistance in Bamako and Chingleput: final report; THELEP

Abstract

ASJC Scopus subject areas

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