Primary dapsone resistance in Bamako and Chingleput: final report; THELEP

M. Christain, M. J. Colston, G. A. Ellard, C. A P Ferracci, J. H. Grosset, G. Grossetete, C. G S Iyer, J. Baohong, K. Lwin, D. L. Leiker, L. Levy, S. K. Noordeen, S. R. Pattyn, J. M H Pearson, R. J W Rees, H. Sansarricq, P. S. Seshadri, J. K. Seydel, C. C. Shepard, M. F R Waters

Research output: Contribution to journalArticle

Abstract

Approximately 37% of the 131 patients with lepromatous leprosy admitted into the THELEP controlled clinical trials in Bamako and Chingleput, whose Myobacterium leprae obtained from pretreatment biopsy specimens could be tested in mice, have been found to harbour dapsone-resistant organisms, and are though to represent instances of primary resistance to dapsone. The majority of these patients harboured strains of a low degree of resistance, one-fifth of these patients harboured organisms of an intermediated resistance, and no patient was found to harbour M. leprae of a high degree of resistance. No relationships were discerned between patient age, number of M. leprae, or disease classification on one hand, and primary resistance to dapsone on the other.

Original languageEnglish (US)
Pages (from-to)209-218
Number of pages10
JournalLeprosy Review
Volume58
Issue number3
StatePublished - 1987
Externally publishedYes

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Dapsone
Lepromatous Leprosy
Controlled Clinical Trials
Biopsy

ASJC Scopus subject areas

  • Dermatology

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Christain, M., Colston, M. J., Ellard, G. A., Ferracci, C. A. P., Grosset, J. H., Grossetete, G., ... Waters, M. F. R. (1987). Primary dapsone resistance in Bamako and Chingleput: final report; THELEP. Leprosy Review, 58(3), 209-218.

Primary dapsone resistance in Bamako and Chingleput : final report; THELEP. / Christain, M.; Colston, M. J.; Ellard, G. A.; Ferracci, C. A P; Grosset, J. H.; Grossetete, G.; Iyer, C. G S; Baohong, J.; Lwin, K.; Leiker, D. L.; Levy, L.; Noordeen, S. K.; Pattyn, S. R.; Pearson, J. M H; Rees, R. J W; Sansarricq, H.; Seshadri, P. S.; Seydel, J. K.; Shepard, C. C.; Waters, M. F R.

In: Leprosy Review, Vol. 58, No. 3, 1987, p. 209-218.

Research output: Contribution to journalArticle

Christain, M, Colston, MJ, Ellard, GA, Ferracci, CAP, Grosset, JH, Grossetete, G, Iyer, CGS, Baohong, J, Lwin, K, Leiker, DL, Levy, L, Noordeen, SK, Pattyn, SR, Pearson, JMH, Rees, RJW, Sansarricq, H, Seshadri, PS, Seydel, JK, Shepard, CC & Waters, MFR 1987, 'Primary dapsone resistance in Bamako and Chingleput: final report; THELEP', Leprosy Review, vol. 58, no. 3, pp. 209-218.
Christain M, Colston MJ, Ellard GA, Ferracci CAP, Grosset JH, Grossetete G et al. Primary dapsone resistance in Bamako and Chingleput: final report; THELEP. Leprosy Review. 1987;58(3):209-218.
Christain, M. ; Colston, M. J. ; Ellard, G. A. ; Ferracci, C. A P ; Grosset, J. H. ; Grossetete, G. ; Iyer, C. G S ; Baohong, J. ; Lwin, K. ; Leiker, D. L. ; Levy, L. ; Noordeen, S. K. ; Pattyn, S. R. ; Pearson, J. M H ; Rees, R. J W ; Sansarricq, H. ; Seshadri, P. S. ; Seydel, J. K. ; Shepard, C. C. ; Waters, M. F R. / Primary dapsone resistance in Bamako and Chingleput : final report; THELEP. In: Leprosy Review. 1987 ; Vol. 58, No. 3. pp. 209-218.
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abstract = "Approximately 37{\%} of the 131 patients with lepromatous leprosy admitted into the THELEP controlled clinical trials in Bamako and Chingleput, whose Myobacterium leprae obtained from pretreatment biopsy specimens could be tested in mice, have been found to harbour dapsone-resistant organisms, and are though to represent instances of primary resistance to dapsone. The majority of these patients harboured strains of a low degree of resistance, one-fifth of these patients harboured organisms of an intermediated resistance, and no patient was found to harbour M. leprae of a high degree of resistance. No relationships were discerned between patient age, number of M. leprae, or disease classification on one hand, and primary resistance to dapsone on the other.",
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T2 - final report; THELEP

AU - Christain, M.

AU - Colston, M. J.

AU - Ellard, G. A.

AU - Ferracci, C. A P

AU - Grosset, J. H.

AU - Grossetete, G.

AU - Iyer, C. G S

AU - Baohong, J.

AU - Lwin, K.

AU - Leiker, D. L.

AU - Levy, L.

AU - Noordeen, S. K.

AU - Pattyn, S. R.

AU - Pearson, J. M H

AU - Rees, R. J W

AU - Sansarricq, H.

AU - Seshadri, P. S.

AU - Seydel, J. K.

AU - Shepard, C. C.

AU - Waters, M. F R

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AB - Approximately 37% of the 131 patients with lepromatous leprosy admitted into the THELEP controlled clinical trials in Bamako and Chingleput, whose Myobacterium leprae obtained from pretreatment biopsy specimens could be tested in mice, have been found to harbour dapsone-resistant organisms, and are though to represent instances of primary resistance to dapsone. The majority of these patients harboured strains of a low degree of resistance, one-fifth of these patients harboured organisms of an intermediated resistance, and no patient was found to harbour M. leprae of a high degree of resistance. No relationships were discerned between patient age, number of M. leprae, or disease classification on one hand, and primary resistance to dapsone on the other.

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