Primary cutaneous T-cell-rich B-cell lymphoma: Clinically distinct from its nodal counterpart?

S. Li, C. A. Griffin, R. B. Mann, Michael J Borowitz

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Abstract

The cases of two patients with Stage IE primary cutaneous T-cell-rich B-cell lymphoma (TCRBCL) are described. In both, the lesion showed a dense infiltrate by numerous small T lymphocytes with scattered histiocytes and large atypical B-lymphoid cells. Polymerase chain reaction assays demonstrated that the B cells were monoclonal, with immunoglobulin heavy-chain gene rearrangement. No clonal rearrangements of the T-cell receptor gamma gene were observed. Both patients were disease-free at 4 months and at 5 years after therapy, respectively. Although rare, primary cutaneous T-cell-rich B-cell lymphoma appears to have a better prognosis than its nodal counterpart, with or without skin involvement.

Original languageEnglish (US)
Pages (from-to)10-13
Number of pages4
JournalModern Pathology
Volume14
Issue number1
DOIs
Publication statusPublished - 2001

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Keywords

  • Gene rearrangement
  • Skin
  • T-cell-rich B-cell lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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