Primary central nervous system gamma delta cytotoxic T-cell lymphoma

Kelly L. Mooney, Winward Choy, Joslyn Woodard, Rena Xian, Taylor M. Deal, Ryan F. Kendle, Jonathan Said, Wayne Grody, Isaac Yang

Research output: Contribution to journalArticle

Abstract

Primary T-cell lymphomas of the central nervous system (CNS) are uncommon, but aggressive and increasing in incidence. We describe a rare case of T-cell lymphoma in a cerebellar location, to our knowledge the first reported case demonstrating gamma/delta receptor expression. Additionally, we elaborate on key diagnostic features and review all nine patients with primary CNS lymphoma of cytotoxic T-cell phenotype reported in the literature. A 26-year-old female medical student presented with a 6 week history of nausea, vomiting and dizziness. MRI revealed a 2 cm cerebellar mass. The tumor was subtotally resected, and pathologic examination of a subtotal resection specimen demonstrated peripheral T-cell lymphoma, not otherwise specified, with a gamma/delta cytotoxic T-cell phenotype. She subsequently started high dose methotrexate and cytarabine. We report a unique case of primary CNS gamma delta CD8+ T-cell lymphoma lineage in a young female patient. While these are rare entities, it is an important differential diagnosis to consider. Therapy should be tailored to the patient, and involves resection with adjuvant chemotherapy, radiotherapy or autologous stem-cell based treatments.

Original languageEnglish (US)
Pages (from-to)138-140
Number of pages3
JournalJournal of Clinical Neuroscience
Volume26
DOIs
StatePublished - Apr 1 2016
Externally publishedYes

Fingerprint

T-Cell Lymphoma
Central Nervous System
Peripheral T-Cell Lymphoma
Phenotype
delta Opioid Receptor
Adjuvant Radiotherapy
Cytarabine
Dizziness
Cell Lineage
Adjuvant Chemotherapy
Medical Students
Methotrexate
Nausea
Vomiting
Differential Diagnosis
Stem Cells
T-Lymphocytes
Incidence
Therapeutics
Neoplasms

Keywords

  • Brain
  • CNS
  • Cytotoxic
  • Gamma/delta
  • Lymphoma
  • T-cell

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Mooney, K. L., Choy, W., Woodard, J., Xian, R., Deal, T. M., Kendle, R. F., ... Yang, I. (2016). Primary central nervous system gamma delta cytotoxic T-cell lymphoma. Journal of Clinical Neuroscience, 26, 138-140. https://doi.org/10.1016/j.jocn.2015.10.017

Primary central nervous system gamma delta cytotoxic T-cell lymphoma. / Mooney, Kelly L.; Choy, Winward; Woodard, Joslyn; Xian, Rena; Deal, Taylor M.; Kendle, Ryan F.; Said, Jonathan; Grody, Wayne; Yang, Isaac.

In: Journal of Clinical Neuroscience, Vol. 26, 01.04.2016, p. 138-140.

Research output: Contribution to journalArticle

Mooney, KL, Choy, W, Woodard, J, Xian, R, Deal, TM, Kendle, RF, Said, J, Grody, W & Yang, I 2016, 'Primary central nervous system gamma delta cytotoxic T-cell lymphoma', Journal of Clinical Neuroscience, vol. 26, pp. 138-140. https://doi.org/10.1016/j.jocn.2015.10.017
Mooney, Kelly L. ; Choy, Winward ; Woodard, Joslyn ; Xian, Rena ; Deal, Taylor M. ; Kendle, Ryan F. ; Said, Jonathan ; Grody, Wayne ; Yang, Isaac. / Primary central nervous system gamma delta cytotoxic T-cell lymphoma. In: Journal of Clinical Neuroscience. 2016 ; Vol. 26. pp. 138-140.
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