Prevention of transfusion-associated cytomegalovirus (Cmv) infection in neonates by screening blood donors for igm to cmv

Harold V. Lamberson, Julia A. McMillan, Leonard B. Weiner, Margaret L. Williams, David A. Clark, Cheryl A. McMahon, Ellyn B. Lentz, Anne Patti Higgins, Nancy L. Dock, Nancy L. Dock

Research output: Contribution to journalArticlepeer-review

Abstract

Various approaches to eliminate transfusion-associated cytomegalovirus (TA-CMV) infection in neonates have been attempted. TA-CMV in neonates has been prevented by using frozen, deglycerolized red blood cells [1, 2]. The use of saline-washed red blood cells has been shown to be effective in reducing TA-CMV in one study [3] but ineffective in another [4], Serological screening to provide CMV-seronegative blood has been shown to be an effective method of prevention in several studies [5, 6] and has the advantage of applicability to all types of blood products. Donor populations, however, vary considerably in their seropositivity rates, a situation thus limiting the available supply of seronegative blood in some areas [7, 8].

Original languageEnglish (US)
Pages (from-to)820-822
Number of pages3
JournalJournal of Infectious Diseases
Volume157
Issue number4
DOIs
StatePublished - Apr 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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