TY - JOUR
T1 - Prevention of prostate cancer
T2 - outcomes of clinical trials and future opportunities
AU - Thompson, Ian
AU - Kristal, Alan
AU - Platz, Elizabeth A.
PY - 2014
Y1 - 2014
N2 - Prostate cancer is an excellent target for prevention, to reduce both mortality and the burden of overdetection of potential inconsequential disease whose diagnosis increases cost, morbidity, and anxiety. The Prostate Cancer Prevention Trial has demonstrated that finasteride significantly reduces the risk of prostate cancer but only low-grade disease; overall survival is unaffected. In the Selenium and Vitamin E Cancer Prevention Trial (SELECT) clinical trial, selenium had no effect on prostate cancer risk, but alpha tocopherol significantly increased the risk by 17%. The most promising future approaches to prostate cancer prevention will likely focus on nutrition, especially weight control, and through modulation of inflammation.
AB - Prostate cancer is an excellent target for prevention, to reduce both mortality and the burden of overdetection of potential inconsequential disease whose diagnosis increases cost, morbidity, and anxiety. The Prostate Cancer Prevention Trial has demonstrated that finasteride significantly reduces the risk of prostate cancer but only low-grade disease; overall survival is unaffected. In the Selenium and Vitamin E Cancer Prevention Trial (SELECT) clinical trial, selenium had no effect on prostate cancer risk, but alpha tocopherol significantly increased the risk by 17%. The most promising future approaches to prostate cancer prevention will likely focus on nutrition, especially weight control, and through modulation of inflammation.
UR - http://www.scopus.com/inward/record.url?scp=84964698761&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84964698761&partnerID=8YFLogxK
U2 - 10.14694/EdBook_AM.2014.34.e76
DO - 10.14694/EdBook_AM.2014.34.e76
M3 - Review article
C2 - 24857150
AN - SCOPUS:84964698761
SN - 1548-8756
SP - e76-e80
JO - American Society of Clinical Oncology educational book / ASCO. American Society of Clinical Oncology. Meeting
JF - American Society of Clinical Oncology educational book / ASCO. American Society of Clinical Oncology. Meeting
ER -