Prevention of phosphate-induced progression of uremia in rats by 3-phosphocitric acid

L. Gimenez, W. G. Walker, W. P. Tew, J. A. Hermann

Research output: Contribution to journalArticlepeer-review

Abstract

Male Sprague-Dawley rats were rendered uremic by surgical removal of 70% of functioning renal mass. This produced a rapid threshold rise in serum creatinine to 0.87 ± 0.067 (SEM) mg/dl at 2 weeks postoperatively which declined subsequently to a value of 0.64 ± 0.06 (SEM) and remained thereafter for an additional 4 weeks in animals maintained on a diet with normal phosphate content. Increase of dietary phosphate content to 2.2% at 2 weeks after surgery produced a significant and progressive increase in serum creatinine to values fourfold higher than the mean values in comparable partially nephrectomized control animals maintained on a diet with normal phosphate content (P < 0.001). This deterioration in renal function was associated with extensive nephrocalcinosis, tubular dilatation, cellular necrosis, and marked interstitial inflammation, 3-phosphocitric acid, a compound which has been shown to prevent calcium phosphate crystal growth as well as to prevent in vivo nephrocalcinosis, was very effective in preventing this phosphate-induced deterioration of renal function and in preventing any significant increase in renal calcium content in animals fed a high phosphate diet. This compound was also effective in preventing the renal histologic changes associated with phosphate-induced uremia.

Original languageEnglish (US)
Pages (from-to)36-41
Number of pages6
JournalKidney international
Volume22
Issue number1
DOIs
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Nephrology

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