Prevention of human immunodeficiency virus-1 transmission to the infant through breastfeeding: new developments

Athena P. Kourtis; Denise J. Jamieson; Isabelle de Vincenzi; Allan Taylor; Michael C. Thigpen; Halima Dao; Timothy Farley; Mary Glenn Fowler

doi:10.1016/j.ajog.2007.03.003

Prevention of human immunodeficiency virus-1 transmission to the infant through breastfeeding: new developments

Athena P. Kourtis, Denise J. Jamieson, Isabelle de Vincenzi, Allan Taylor, Michael C. Thigpen, Halima Dao, Timothy Farley, Mary Glenn Fowler

School of Medicine

Research output: Contribution to journal › Review article › peer-review

39 Scopus citations

Abstract

Breastfeeding accounts for up to half of all infant human immunodeficiency virus (HIV) infections worldwide and carries an estimated transmission risk of about 15% when continued into the second year of life. Because replacement feeding is not safely available, culturally acceptable, or affordable in many parts of the world and because breastfeeding provides protection against other causes of infant mortality, approaches that reduce breastfeeding mother-to child transmission of HIV are being explored. These include exclusive breastfeeding for the infant's first few months of life followed by rapid weaning, treatments of expressed milk to inactivate the virus, and antiretroviral prophylaxis taken by the infant or mother during breastfeeding, which are strategies currently being tested in clinical trials. Passive (antibodies) and active (vaccine) immunoprophylaxis will also soon begin to be tested. This paper focuses on current and planned research on strategies to prevent breastfeeding transmission of HIV.

Original language	English (US)
Pages (from-to)	S113-S122
Journal	American journal of obstetrics and gynecology
Volume	197
Issue number	3 SUPPL.
DOIs	https://doi.org/10.1016/j.ajog.2007.03.003
State	Published - Sep 2007

Keywords

breast milk
human immunodeficiency virus
infant
prevention
transmission

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/j.ajog.2007.03.003

Cite this

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title = "Prevention of human immunodeficiency virus-1 transmission to the infant through breastfeeding: new developments",

abstract = "Breastfeeding accounts for up to half of all infant human immunodeficiency virus (HIV) infections worldwide and carries an estimated transmission risk of about 15% when continued into the second year of life. Because replacement feeding is not safely available, culturally acceptable, or affordable in many parts of the world and because breastfeeding provides protection against other causes of infant mortality, approaches that reduce breastfeeding mother-to child transmission of HIV are being explored. These include exclusive breastfeeding for the infant's first few months of life followed by rapid weaning, treatments of expressed milk to inactivate the virus, and antiretroviral prophylaxis taken by the infant or mother during breastfeeding, which are strategies currently being tested in clinical trials. Passive (antibodies) and active (vaccine) immunoprophylaxis will also soon begin to be tested. This paper focuses on current and planned research on strategies to prevent breastfeeding transmission of HIV.",

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author = "Kourtis, {Athena P.} and Jamieson, {Denise J.} and {de Vincenzi}, Isabelle and Allan Taylor and Thigpen, {Michael C.} and Halima Dao and Timothy Farley and Fowler, {Mary Glenn}",

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AU - Kourtis, Athena P.

AU - Jamieson, Denise J.

AU - de Vincenzi, Isabelle

AU - Taylor, Allan

AU - Thigpen, Michael C.

AU - Dao, Halima

AU - Farley, Timothy

AU - Fowler, Mary Glenn

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AB - Breastfeeding accounts for up to half of all infant human immunodeficiency virus (HIV) infections worldwide and carries an estimated transmission risk of about 15% when continued into the second year of life. Because replacement feeding is not safely available, culturally acceptable, or affordable in many parts of the world and because breastfeeding provides protection against other causes of infant mortality, approaches that reduce breastfeeding mother-to child transmission of HIV are being explored. These include exclusive breastfeeding for the infant's first few months of life followed by rapid weaning, treatments of expressed milk to inactivate the virus, and antiretroviral prophylaxis taken by the infant or mother during breastfeeding, which are strategies currently being tested in clinical trials. Passive (antibodies) and active (vaccine) immunoprophylaxis will also soon begin to be tested. This paper focuses on current and planned research on strategies to prevent breastfeeding transmission of HIV.

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ER -

Prevention of human immunodeficiency virus-1 transmission to the infant through breastfeeding: new developments

Abstract

Keywords

ASJC Scopus subject areas

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