TY - JOUR
T1 - Prevention of Haemophilus influenzae Type b Infections in High-Risk Infants Treated with Bacterial Polysaccharide Immune Globulin
AU - Santosham, Mathuram
AU - Reid, Raymond
AU - Ambrosino, Donna M.
AU - Wolff, Mark C.
AU - Almeido-Hill, Janne
AU - Priehs, Claudette
AU - Aspery, Kathy M.
AU - Garrett, Steve
AU - Croll, Larry
AU - Foster, Stephan
AU - Burge, Gerald
AU - Page, Peter
AU - Zacher, Bonnie
AU - Moxon, Richard
AU - Siber, George R.
PY - 1987/10/8
Y1 - 1987/10/8
N2 - Apache Indian infants have a high frequency of Haemophilus influenzae type b (Hib) and pneumococcal infections. Forty percent of Hib infections in these infants occur before the age of six months, when active immunization may not be protective. To evaluate the efficacy of passive immunization with a human hyperimmune globulin (bacterial polysaccharide immune globulin [BPIG]) prepared from the plasma of immunized adult donors, we randomly assigned 703 infants in a double-blind fashion to receive 0.5 ml of BPIG per kilogram of body weight (n = 353) or 0.5 ml of saline (n = 350) intramuscularly at 2, 6, and 10 months of age. Hib-antibody levels were significantly higher in BPIG recipients than in placebo recipients at 4, 6, and 10 months of age (P<0.001). During the first 90 days after BPIG or, HAEMOPHILUS influenzae type b (Hib) is an important cause of serious infections in infants and children.1 2 3 In the United States the highest attack rates of meningitis and other bacteremic infections due to Hib have been documented among certain American Indian and Alaskan Eskimo populations.4,5 In these high-risk groups, the majority of invasive Hib infections have occurred in children under one year of age, with up to 40 percent of cases occurring before six months of age.4,5 Therefore, prevention of Hib infections in young infants is a high priority for these populations. The currently licensed Hib vaccine consists of the purified…
AB - Apache Indian infants have a high frequency of Haemophilus influenzae type b (Hib) and pneumococcal infections. Forty percent of Hib infections in these infants occur before the age of six months, when active immunization may not be protective. To evaluate the efficacy of passive immunization with a human hyperimmune globulin (bacterial polysaccharide immune globulin [BPIG]) prepared from the plasma of immunized adult donors, we randomly assigned 703 infants in a double-blind fashion to receive 0.5 ml of BPIG per kilogram of body weight (n = 353) or 0.5 ml of saline (n = 350) intramuscularly at 2, 6, and 10 months of age. Hib-antibody levels were significantly higher in BPIG recipients than in placebo recipients at 4, 6, and 10 months of age (P<0.001). During the first 90 days after BPIG or, HAEMOPHILUS influenzae type b (Hib) is an important cause of serious infections in infants and children.1 2 3 In the United States the highest attack rates of meningitis and other bacteremic infections due to Hib have been documented among certain American Indian and Alaskan Eskimo populations.4,5 In these high-risk groups, the majority of invasive Hib infections have occurred in children under one year of age, with up to 40 percent of cases occurring before six months of age.4,5 Therefore, prevention of Hib infections in young infants is a high priority for these populations. The currently licensed Hib vaccine consists of the purified…
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U2 - 10.1056/NEJM198710083171503
DO - 10.1056/NEJM198710083171503
M3 - Article
C2 - 2442610
AN - SCOPUS:0023281205
SN - 0028-4793
VL - 317
SP - 923
EP - 929
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 15
ER -