Prevention of Haemophilus influenzae Type b Infections in Apache and Navajo Children

Mathuram Santosham, Beth Rivin, Mark Wolff, Raymond Reid, Wendy Newcomer, G. William Letson, Janné Almeido-Hill, Claudette Thompson, George R. Siber

Research output: Contribution to journalArticle

Abstract

Prospective surveillance of Haemophilus influenzae type b (Hib) disease has been done since 1981 in two high-risk populations, White Mountain Apaches and Navajos. The attack rate in children <5 years of age is 5-10 times higher than in the general US population. Three vaccines were evaluated. Unconjugated Hib capsular polysaccharide produced lower antibody responses in 18- and 24-month-old Apache infants than in white infants. HbOC (Hib oligosaccharide covalently linked to the nontoxic mutant diphtheria toxin CRM197) produced low antibody responses in Navajo infants after one or two doses but induced responses similar to those in whites after three doses. The responses of 18-month-old Navajos to HbOC were lower than those of whites, but most achieved protective levels. PRP-OMP (Hib capsular polysaccharide linked to the outer membrane protein complex of Neisseria meningitidis) produced good immune responses in 2-month-old Navajo and Apache infants after a single dose. This vaccine was >90% efficacious in protecting Navajo infants from Hib disease when given at 2 and 4 months of age. Even a single dose achieved a high protective efficacy.

Original languageEnglish (US)
Pages (from-to)S144-S151
JournalJournal of Infectious Diseases
Volume165
DOIs
StatePublished - Jun 1992

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Santosham, M., Rivin, B., Wolff, M., Reid, R., Newcomer, W., William Letson, G., Almeido-Hill, J., Thompson, C., & Siber, G. R. (1992). Prevention of Haemophilus influenzae Type b Infections in Apache and Navajo Children. Journal of Infectious Diseases, 165, S144-S151. https://doi.org/10.1093/infdis/165-Supplement_1-S144