Abstract
Haemophilus influenzae type b (Hib) is responsible for significant morbidity and mortality worldwide, particularly in children under 5 years of age. In countries where the Hib conjugate vaccine is not routinely used, Hib is a leading cause of childhood pneumonia and meningitis. Routine use of the Hib conjugate vaccines has resulted in a remarkable decline in Hib disease in developed and developing countries. However, Hib conjugate vaccines are not routinely available in most developing countries, many of which have high burdens of Hib disease. This review outlines the pathogenesis and epidemiology of Hib disease, and the various options for prevention.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 819-827 |
| Number of pages | 9 |
| Journal | Expert Review of Vaccines |
| Volume | 4 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2005 |
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Keywords
- Developing countries
- Haemophilus influenzae type b
- Hib
- Menegitis
- Pneumonia
- Prevention
- Vaccines
ASJC Scopus subject areas
- Immunology
- Pharmacology
Cite this
Prevention of Haemophilus influenzae type b disease : Past success and future challenges. / Chandran, Aruna; Watt, James P.; Santosham, Mathuram.
In: Expert Review of Vaccines, Vol. 4, No. 6, 12.2005, p. 819-827.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prevention of Haemophilus influenzae type b disease
T2 - Past success and future challenges
AU - Chandran, Aruna
AU - Watt, James P.
AU - Santosham, Mathuram
PY - 2005/12
Y1 - 2005/12
N2 - Haemophilus influenzae type b (Hib) is responsible for significant morbidity and mortality worldwide, particularly in children under 5 years of age. In countries where the Hib conjugate vaccine is not routinely used, Hib is a leading cause of childhood pneumonia and meningitis. Routine use of the Hib conjugate vaccines has resulted in a remarkable decline in Hib disease in developed and developing countries. However, Hib conjugate vaccines are not routinely available in most developing countries, many of which have high burdens of Hib disease. This review outlines the pathogenesis and epidemiology of Hib disease, and the various options for prevention.
AB - Haemophilus influenzae type b (Hib) is responsible for significant morbidity and mortality worldwide, particularly in children under 5 years of age. In countries where the Hib conjugate vaccine is not routinely used, Hib is a leading cause of childhood pneumonia and meningitis. Routine use of the Hib conjugate vaccines has resulted in a remarkable decline in Hib disease in developed and developing countries. However, Hib conjugate vaccines are not routinely available in most developing countries, many of which have high burdens of Hib disease. This review outlines the pathogenesis and epidemiology of Hib disease, and the various options for prevention.
KW - Developing countries
KW - Haemophilus influenzae type b
KW - Hib
KW - Menegitis
KW - Pneumonia
KW - Prevention
KW - Vaccines
UR - http://www.scopus.com/inward/record.url?scp=29944440591&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=29944440591&partnerID=8YFLogxK
U2 - 10.1586/14760584.4.6.819
DO - 10.1586/14760584.4.6.819
M3 - Article
C2 - 16372878
AN - SCOPUS:29944440591
VL - 4
SP - 819
EP - 827
JO - Expert Review of Vaccines
JF - Expert Review of Vaccines
SN - 1476-0584
IS - 6
ER -