Prevention of Haemophilus influenzae type b disease: Past success and future challenges

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Haemophilus influenzae type b (Hib) is responsible for significant morbidity and mortality worldwide, particularly in children under 5 years of age. In countries where the Hib conjugate vaccine is not routinely used, Hib is a leading cause of childhood pneumonia and meningitis. Routine use of the Hib conjugate vaccines has resulted in a remarkable decline in Hib disease in developed and developing countries. However, Hib conjugate vaccines are not routinely available in most developing countries, many of which have high burdens of Hib disease. This review outlines the pathogenesis and epidemiology of Hib disease, and the various options for prevention.

Original languageEnglish (US)
Pages (from-to)819-827
Number of pages9
JournalExpert review of vaccines
Issue number6
StatePublished - Dec 2005


  • Developing countries
  • Haemophilus influenzae type b
  • Hib
  • Menegitis
  • Pneumonia
  • Prevention
  • Vaccines

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery


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