Prevention of depression in medical conditions

Liming Dong, Joseph J. Gallo

Research output: Chapter in Book/Report/Conference proceedingChapter


In this chapter, we provide an overview of the relationship between physical health and depression, including excess disability and mortality associated with depression, and discuss what we know about prevention of depression in the context of medical conditions such as diabetes and cardiovascular disease. We describe a conceptual framework linking depression and medical illness, with a literature review of randomized controlled trials of prevention that recruited nondepressed persons with at least one physical disorder. Most of the reported studies, though not all, showed that pharmacologic or non-pharmacologic strategies can reduce rates of depression. Methodologic considerations and future directions are described. Prevention of depression in the context of medical conditions is a new field with implications for research, policy, and practice.

Original languageEnglish (US)
Title of host publicationPrevention of Late-Life Depression
Subtitle of host publicationCurrent Clinical Challenges and Priorities
PublisherSpringer International Publishing
Number of pages24
ISBN (Electronic)9783319160450
ISBN (Print)9783319160443
StatePublished - Jan 1 2015


  • Cancer
  • Cardiovascular disease
  • Diabetes
  • Medical comorbidity
  • Mortality
  • Primary health care

ASJC Scopus subject areas

  • Medicine(all)


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