Prevention and Management of Graft-versus-Host Disease: Practical Recommendations

Georgia Boyce Vogelsang, Lawrence E. Morris

Research output: Contribution to journalArticle

Abstract

Graft-versus-host disease (GVHD) is the leading cause of failure of allogeneic bone marrow transplantation. The disease typically involves the skin, liver and gastrointestinal tract, with death frequently resulting from infectious complications. Cyclosporin-based drug combinations are the mainstay of GVHD prophylaxis. The major toxicity of cyclosporin is renal dysfunction, and optimal strategies of therapeutic drug monitoring to minimise toxicity and maximise clinical efficacy have yet to be devised. Initial treatment of established GVHD usually includes high dose corticosteroids. Patients failing to respond to first line therapy have a poor prognosis. Investigational approaches to decreasing the mortality associated with GVHD include using monoclonal antibodies directed at specific T cell subsets, and T cell depletion of bone marrow grafts.

Original languageEnglish (US)
Pages (from-to)668-676
Number of pages9
JournalDrugs
Volume45
Issue number5
DOIs
StatePublished - 1993

Fingerprint

Graft vs Host Disease
Grafts
T-cells
Cyclosporine
Toxicity
Bone
Drug Monitoring
Homologous Transplantation
T-Lymphocyte Subsets
Drug Combinations
Bone Marrow Transplantation
Gastrointestinal Tract
Adrenal Cortex Hormones
Liver
Bone Marrow
Monoclonal Antibodies
T-Lymphocytes
Transplants
Skin
Kidney

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Health, Toxicology and Mutagenesis
  • Toxicology

Cite this

Prevention and Management of Graft-versus-Host Disease : Practical Recommendations. / Vogelsang, Georgia Boyce; Morris, Lawrence E.

In: Drugs, Vol. 45, No. 5, 1993, p. 668-676.

Research output: Contribution to journalArticle

@article{043a49448b88424f93cbb017d0b79918,
title = "Prevention and Management of Graft-versus-Host Disease: Practical Recommendations",
abstract = "Graft-versus-host disease (GVHD) is the leading cause of failure of allogeneic bone marrow transplantation. The disease typically involves the skin, liver and gastrointestinal tract, with death frequently resulting from infectious complications. Cyclosporin-based drug combinations are the mainstay of GVHD prophylaxis. The major toxicity of cyclosporin is renal dysfunction, and optimal strategies of therapeutic drug monitoring to minimise toxicity and maximise clinical efficacy have yet to be devised. Initial treatment of established GVHD usually includes high dose corticosteroids. Patients failing to respond to first line therapy have a poor prognosis. Investigational approaches to decreasing the mortality associated with GVHD include using monoclonal antibodies directed at specific T cell subsets, and T cell depletion of bone marrow grafts.",
author = "Vogelsang, {Georgia Boyce} and Morris, {Lawrence E.}",
year = "1993",
doi = "10.2165/00003495-199345050-00004",
language = "English (US)",
volume = "45",
pages = "668--676",
journal = "Drugs",
issn = "0012-6667",
publisher = "Adis International Ltd",
number = "5",

}

TY - JOUR

T1 - Prevention and Management of Graft-versus-Host Disease

T2 - Practical Recommendations

AU - Vogelsang, Georgia Boyce

AU - Morris, Lawrence E.

PY - 1993

Y1 - 1993

N2 - Graft-versus-host disease (GVHD) is the leading cause of failure of allogeneic bone marrow transplantation. The disease typically involves the skin, liver and gastrointestinal tract, with death frequently resulting from infectious complications. Cyclosporin-based drug combinations are the mainstay of GVHD prophylaxis. The major toxicity of cyclosporin is renal dysfunction, and optimal strategies of therapeutic drug monitoring to minimise toxicity and maximise clinical efficacy have yet to be devised. Initial treatment of established GVHD usually includes high dose corticosteroids. Patients failing to respond to first line therapy have a poor prognosis. Investigational approaches to decreasing the mortality associated with GVHD include using monoclonal antibodies directed at specific T cell subsets, and T cell depletion of bone marrow grafts.

AB - Graft-versus-host disease (GVHD) is the leading cause of failure of allogeneic bone marrow transplantation. The disease typically involves the skin, liver and gastrointestinal tract, with death frequently resulting from infectious complications. Cyclosporin-based drug combinations are the mainstay of GVHD prophylaxis. The major toxicity of cyclosporin is renal dysfunction, and optimal strategies of therapeutic drug monitoring to minimise toxicity and maximise clinical efficacy have yet to be devised. Initial treatment of established GVHD usually includes high dose corticosteroids. Patients failing to respond to first line therapy have a poor prognosis. Investigational approaches to decreasing the mortality associated with GVHD include using monoclonal antibodies directed at specific T cell subsets, and T cell depletion of bone marrow grafts.

UR - http://www.scopus.com/inward/record.url?scp=0027155517&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027155517&partnerID=8YFLogxK

U2 - 10.2165/00003495-199345050-00004

DO - 10.2165/00003495-199345050-00004

M3 - Article

C2 - 7686462

AN - SCOPUS:0027155517

VL - 45

SP - 668

EP - 676

JO - Drugs

JF - Drugs

SN - 0012-6667

IS - 5

ER -