TY - JOUR
T1 - Preventing Postnatal Transmission of HIV-1 Through Breast-feeding
T2 - Modifying Infant Feeding Practices
AU - Rollins, Nigel
AU - Meda, Nicolas
AU - Becquet, Renaud
AU - Coutsoudis, Anna
AU - Humphrey, Jean
AU - Jeffrey, Barbara
AU - Kanshana, Siripon
AU - Kuhn, Louise
AU - Leroy, Valeriane
AU - Mbori-Ngacha, Dorothy
AU - McIntyre, James
AU - Newell, Marie Louise
PY - 2004/2/1
Y1 - 2004/2/1
N2 - Approaches to reducing or preventing the risk of postnatal transmission through breast-feeding include the avoidance of all breast-feeding and the use of exclusive replacement feeds or exclusive breast-feeding for a limited duration with early and rapid cessation of breast-feeding around 4-6 months of age. The efficacy and safety of the latter approach have not been established and studies are in progress to provide further information. In addition, inactivation of HIV in breast milk would allow breast-feeding to continue while reducing the risk of postnatal transmission of HIV and may be usefully applied in certain circumstances, such as for premature infants or while a mother recovers from mastitis. In this review, experience is reported from clinical trials or studies additional to their main objective of assessing rates and risk factors for mother-to-child transmission. This may inform policy, programming, and training options and may be especially valuable in the absence of conclusive data on the efficacy of the interventions to be applied during the breast-feeding period.
AB - Approaches to reducing or preventing the risk of postnatal transmission through breast-feeding include the avoidance of all breast-feeding and the use of exclusive replacement feeds or exclusive breast-feeding for a limited duration with early and rapid cessation of breast-feeding around 4-6 months of age. The efficacy and safety of the latter approach have not been established and studies are in progress to provide further information. In addition, inactivation of HIV in breast milk would allow breast-feeding to continue while reducing the risk of postnatal transmission of HIV and may be usefully applied in certain circumstances, such as for premature infants or while a mother recovers from mastitis. In this review, experience is reported from clinical trials or studies additional to their main objective of assessing rates and risk factors for mother-to-child transmission. This may inform policy, programming, and training options and may be especially valuable in the absence of conclusive data on the efficacy of the interventions to be applied during the breast-feeding period.
KW - Breastfeeding
KW - Infant feeding practices
KW - Postnatal transmission
KW - Prevention
UR - http://www.scopus.com/inward/record.url?scp=9144230029&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=9144230029&partnerID=8YFLogxK
U2 - 10.1097/00126334-200402010-00014
DO - 10.1097/00126334-200402010-00014
M3 - Review article
C2 - 14722453
AN - SCOPUS:9144230029
VL - 35
SP - 188
EP - 195
JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
SN - 1525-4135
IS - 2
ER -