Preventing diabetes in obese Latino youth with prediabetes: A study protocol for a randomized controlled trial

Erica G. Soltero; Yolanda P. Konopken; Micah L. Olson; Colleen S. Keller; Felipe G. Castro; Allison N. Williams; Donald L. Patrick; Stephanie Ayers; Houchun H. Hu; Matthew Sandoval; Janiel Pimentel; William C. Knowler; Kevin D. Frick; Gabriel Q. Shaibi

doi:10.1186/s12889-017-4174-2

Preventing diabetes in obese Latino youth with prediabetes: A study protocol for a randomized controlled trial

Erica G. Soltero, Yolanda P. Konopken, Micah L. Olson, Colleen S. Keller, Felipe G. Castro, Allison N. Williams, Donald L. Patrick, Stephanie Ayers, Houchun H. Hu, Matthew Sandoval, Janiel Pimentel, William C. Knowler, Kevin D. Frick, Gabriel Q. Shaibi

Carey Business School

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background: Obese Latino adolescents are disproportionately impacted by insulin resistance and type 2 diabetes. Prediabetes is an intermediate stage in the pathogenesis of type 2 diabetes and represents a critical opportunity for intervention. However, to date, no diabetes prevention studies have been conducted in obese Latino youth with prediabetes, a highly vulnerable and underserved group. Therefore, we propose a randomized-controlled trial to test the short-term (6-month) and long-term (12-month) efficacy of a culturally-grounded, lifestyle intervention, as compared to usual care, for improving glucose tolerance and reducing diabetes risk in 120 obese Latino adolescents with prediabetes. Methods: Participants will be randomized to a lifestyle intervention or usual care group. Participants in the intervention group will attend weekly nutrition and wellness sessions and physical activity sessions twice a week for six months, followed by three months of booster sessions. The overall approach of the intervention is framed within a multilevel Ecodevelopmental model that leverages community, family, peer, and individual factors during the critical transition period of adolescence. The intervention is also guided by Social Cognitive Theory and employs key behavioral modification strategies to enhance self-efficacy and foster social support for making and sustaining healthy behavior changes. We will test intervention effects on quality of life, explore the potential mediating effects of changes in body composition, total, regional, and organ fat on improving glucose tolerance and increasing insulin sensitivity, and estimate the initial incremental cost effectiveness of the intervention as compared with usual care for improving glucose tolerance. Discussion: The proposed trial builds upon extant collaborations of a transdisciplinary team of investigators working in concert with local community agencies to address critical gaps in how diabetes prevention interventions for obese Latino youth are developed, implemented and evaluated. This innovative approach is an essential step in the development of scalable, cost-effective, solution oriented programs to prevent type 2 diabetes in this and other populations of high-risk youth. Trial Registration: NCT0261535 3, registered on June 8, 2016.

Original language	English (US)
Article number	261
Journal	BMC public health
Volume	17
Issue number	1
DOIs	https://doi.org/10.1186/s12889-017-4174-2
State	Published - Mar 16 2017

Keywords

Adolescents
Diabetes prevention
Disparities
Intervention
Latino
Obesity

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

Access to Document

10.1186/s12889-017-4174-2

Cite this

Soltero, E. G., Konopken, Y. P., Olson, M. L., Keller, C. S., Castro, F. G., Williams, A. N., Patrick, D. L., Ayers, S., Hu, H. H., Sandoval, M., Pimentel, J., Knowler, W. C., Frick, K. D., & Shaibi, G. Q. (2017). Preventing diabetes in obese Latino youth with prediabetes: A study protocol for a randomized controlled trial. BMC public health, 17(1), Article 261. https://doi.org/10.1186/s12889-017-4174-2

Soltero, EG, Konopken, YP, Olson, ML, Keller, CS, Castro, FG, Williams, AN, Patrick, DL, Ayers, S, Hu, HH, Sandoval, M, Pimentel, J, Knowler, WC, Frick, KD & Shaibi, GQ 2017, 'Preventing diabetes in obese Latino youth with prediabetes: A study protocol for a randomized controlled trial', BMC public health, vol. 17, no. 1, 261. https://doi.org/10.1186/s12889-017-4174-2

@article{0ec8b3c709874e6a91d6e644fa339f07,

title = "Preventing diabetes in obese Latino youth with prediabetes: A study protocol for a randomized controlled trial",

abstract = "Background: Obese Latino adolescents are disproportionately impacted by insulin resistance and type 2 diabetes. Prediabetes is an intermediate stage in the pathogenesis of type 2 diabetes and represents a critical opportunity for intervention. However, to date, no diabetes prevention studies have been conducted in obese Latino youth with prediabetes, a highly vulnerable and underserved group. Therefore, we propose a randomized-controlled trial to test the short-term (6-month) and long-term (12-month) efficacy of a culturally-grounded, lifestyle intervention, as compared to usual care, for improving glucose tolerance and reducing diabetes risk in 120 obese Latino adolescents with prediabetes. Methods: Participants will be randomized to a lifestyle intervention or usual care group. Participants in the intervention group will attend weekly nutrition and wellness sessions and physical activity sessions twice a week for six months, followed by three months of booster sessions. The overall approach of the intervention is framed within a multilevel Ecodevelopmental model that leverages community, family, peer, and individual factors during the critical transition period of adolescence. The intervention is also guided by Social Cognitive Theory and employs key behavioral modification strategies to enhance self-efficacy and foster social support for making and sustaining healthy behavior changes. We will test intervention effects on quality of life, explore the potential mediating effects of changes in body composition, total, regional, and organ fat on improving glucose tolerance and increasing insulin sensitivity, and estimate the initial incremental cost effectiveness of the intervention as compared with usual care for improving glucose tolerance. Discussion: The proposed trial builds upon extant collaborations of a transdisciplinary team of investigators working in concert with local community agencies to address critical gaps in how diabetes prevention interventions for obese Latino youth are developed, implemented and evaluated. This innovative approach is an essential step in the development of scalable, cost-effective, solution oriented programs to prevent type 2 diabetes in this and other populations of high-risk youth. Trial Registration: NCT0261535 3, registered on June 8, 2016.",

keywords = "Adolescents, Diabetes prevention, Disparities, Intervention, Latino, Obesity",

author = "Soltero, {Erica G.} and Konopken, {Yolanda P.} and Olson, {Micah L.} and Keller, {Colleen S.} and Castro, {Felipe G.} and Williams, {Allison N.} and Patrick, {Donald L.} and Stephanie Ayers and Hu, {Houchun H.} and Matthew Sandoval and Janiel Pimentel and Knowler, {William C.} and Frick, {Kevin D.} and Shaibi, {Gabriel Q.}",

note = "Publisher Copyright: {\textcopyright} 2017 The Author(s).",

year = "2017",

month = mar,

day = "16",

doi = "10.1186/s12889-017-4174-2",

language = "English (US)",

volume = "17",

journal = "BMC public health",

issn = "1471-2458",

publisher = "BioMed Central",

number = "1",

}

TY - JOUR

T1 - Preventing diabetes in obese Latino youth with prediabetes

T2 - A study protocol for a randomized controlled trial

AU - Soltero, Erica G.

AU - Konopken, Yolanda P.

AU - Olson, Micah L.

AU - Keller, Colleen S.

AU - Castro, Felipe G.

AU - Williams, Allison N.

AU - Patrick, Donald L.

AU - Ayers, Stephanie

AU - Hu, Houchun H.

AU - Sandoval, Matthew

AU - Pimentel, Janiel

AU - Knowler, William C.

AU - Frick, Kevin D.

AU - Shaibi, Gabriel Q.

PY - 2017/3/16

Y1 - 2017/3/16

N2 - Background: Obese Latino adolescents are disproportionately impacted by insulin resistance and type 2 diabetes. Prediabetes is an intermediate stage in the pathogenesis of type 2 diabetes and represents a critical opportunity for intervention. However, to date, no diabetes prevention studies have been conducted in obese Latino youth with prediabetes, a highly vulnerable and underserved group. Therefore, we propose a randomized-controlled trial to test the short-term (6-month) and long-term (12-month) efficacy of a culturally-grounded, lifestyle intervention, as compared to usual care, for improving glucose tolerance and reducing diabetes risk in 120 obese Latino adolescents with prediabetes. Methods: Participants will be randomized to a lifestyle intervention or usual care group. Participants in the intervention group will attend weekly nutrition and wellness sessions and physical activity sessions twice a week for six months, followed by three months of booster sessions. The overall approach of the intervention is framed within a multilevel Ecodevelopmental model that leverages community, family, peer, and individual factors during the critical transition period of adolescence. The intervention is also guided by Social Cognitive Theory and employs key behavioral modification strategies to enhance self-efficacy and foster social support for making and sustaining healthy behavior changes. We will test intervention effects on quality of life, explore the potential mediating effects of changes in body composition, total, regional, and organ fat on improving glucose tolerance and increasing insulin sensitivity, and estimate the initial incremental cost effectiveness of the intervention as compared with usual care for improving glucose tolerance. Discussion: The proposed trial builds upon extant collaborations of a transdisciplinary team of investigators working in concert with local community agencies to address critical gaps in how diabetes prevention interventions for obese Latino youth are developed, implemented and evaluated. This innovative approach is an essential step in the development of scalable, cost-effective, solution oriented programs to prevent type 2 diabetes in this and other populations of high-risk youth. Trial Registration: NCT0261535 3, registered on June 8, 2016.

AB - Background: Obese Latino adolescents are disproportionately impacted by insulin resistance and type 2 diabetes. Prediabetes is an intermediate stage in the pathogenesis of type 2 diabetes and represents a critical opportunity for intervention. However, to date, no diabetes prevention studies have been conducted in obese Latino youth with prediabetes, a highly vulnerable and underserved group. Therefore, we propose a randomized-controlled trial to test the short-term (6-month) and long-term (12-month) efficacy of a culturally-grounded, lifestyle intervention, as compared to usual care, for improving glucose tolerance and reducing diabetes risk in 120 obese Latino adolescents with prediabetes. Methods: Participants will be randomized to a lifestyle intervention or usual care group. Participants in the intervention group will attend weekly nutrition and wellness sessions and physical activity sessions twice a week for six months, followed by three months of booster sessions. The overall approach of the intervention is framed within a multilevel Ecodevelopmental model that leverages community, family, peer, and individual factors during the critical transition period of adolescence. The intervention is also guided by Social Cognitive Theory and employs key behavioral modification strategies to enhance self-efficacy and foster social support for making and sustaining healthy behavior changes. We will test intervention effects on quality of life, explore the potential mediating effects of changes in body composition, total, regional, and organ fat on improving glucose tolerance and increasing insulin sensitivity, and estimate the initial incremental cost effectiveness of the intervention as compared with usual care for improving glucose tolerance. Discussion: The proposed trial builds upon extant collaborations of a transdisciplinary team of investigators working in concert with local community agencies to address critical gaps in how diabetes prevention interventions for obese Latino youth are developed, implemented and evaluated. This innovative approach is an essential step in the development of scalable, cost-effective, solution oriented programs to prevent type 2 diabetes in this and other populations of high-risk youth. Trial Registration: NCT0261535 3, registered on June 8, 2016.

KW - Adolescents

KW - Diabetes prevention

KW - Disparities

KW - Intervention

KW - Latino

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=85015299919&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85015299919&partnerID=8YFLogxK

U2 - 10.1186/s12889-017-4174-2

DO - 10.1186/s12889-017-4174-2

M3 - Article

C2 - 28302101

AN - SCOPUS:85015299919

SN - 1471-2458

VL - 17

JO - BMC public health

JF - BMC public health

IS - 1

M1 - 261

ER -

Preventing diabetes in obese Latino youth with prediabetes: A study protocol for a randomized controlled trial

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this