TY - JOUR
T1 - Preventing chronic pain following acute pain
T2 - Risk factors, preventive strategies, and their efficacy
AU - McGreevy, Kai
AU - Bottros, Michael M.
AU - Raja, Srinivasa N.
N1 - Funding Information:
Srinivasa Raja was funded in part by NIH Grant, NS-26363 .
PY - 2011/11
Y1 - 2011/11
N2 - Chronic pain is the leading cause of disability in the United States. The transition from acute to persistent pain is thought to arise from maladaptive neuroplastic mechanisms involving three intertwined processes, peripheral sensitization, central sensitization, and descending modulation. Strategies aimed at preventing persistent pain may target such processes. Models for studying preventive strategies include persistent post-surgical pain (PPP), persistent post-trauma pain (PTP) and post-herpetic neuralgia (PHN). Such entities allow a more defined acute onset of tissue injury after which study of the long-term effects is more easily examined. In this review, we examine the pathophysiology, epidemiology, risk factors, and treatment strategies for the prevention of chronic pain using these models. Both pharmacological and interventional approaches are described, as well as a discussion of preventive strategies on the horizon.
AB - Chronic pain is the leading cause of disability in the United States. The transition from acute to persistent pain is thought to arise from maladaptive neuroplastic mechanisms involving three intertwined processes, peripheral sensitization, central sensitization, and descending modulation. Strategies aimed at preventing persistent pain may target such processes. Models for studying preventive strategies include persistent post-surgical pain (PPP), persistent post-trauma pain (PTP) and post-herpetic neuralgia (PHN). Such entities allow a more defined acute onset of tissue injury after which study of the long-term effects is more easily examined. In this review, we examine the pathophysiology, epidemiology, risk factors, and treatment strategies for the prevention of chronic pain using these models. Both pharmacological and interventional approaches are described, as well as a discussion of preventive strategies on the horizon.
KW - Chronic
KW - Persistent post-surgical pain
KW - Post-traumatic pain
KW - Prevention
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U2 - 10.1016/j.eujps.2011.08.013
DO - 10.1016/j.eujps.2011.08.013
M3 - Article
C2 - 22102847
AN - SCOPUS:83355160657
SN - 1754-3207
VL - 5
SP - 365
EP - 376
JO - European Journal of Pain Supplements
JF - European Journal of Pain Supplements
IS - 2
ER -