Preventative effect of mebendazole against malignancies in neurofibromatosis 1

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Abstract

Patients with RASopathy Neurofibromatosis 1 (NF1) are at a markedly increased risk of the development of benign and malignant tumors. Malignant tumors are often recalcitrant to treatments and associated with poor survival; however, no chemopreventative strategies currently exist. We thus evaluated the effect of mebendazole, alone or in combination with cyclooxygenase-2 (COX-2) inhibitors, on the prevention of NF1-related malignancies in a cis Nf1+/-;Tp53+/-(NPcis) mouse model of NF1. Our in vitro findings showed that mebendazole (MBZ) inhibits the growth of NF1-related malignant peripheral nerve sheath tumors (MPNSTs) through a reduction in activated guanosine triphosphate (GTP)-bound Ras. The daily MBZ treatment of NPcis mice dosed at 195 mg/kg daily, initiated 60 days after birth, substantially delayed the formation of solid malignancies and increased median survival (p < 0.0001). Compared to placebo-treated mice, phosphorylated extracellular signal-regulated kinase (pERK) levels were decreased in the malignancies of MBZ-treated mice. The combination of MBZ with COX-2 inhibitor celecoxib (CXB) further enhanced the chemopreventative effect in female mice beyond each drug alone. These findings demonstrate the feasibility of a prevention strategy for malignancy development in high-risk NF1 individuals.

Original languageEnglish (US)
Article number762
Pages (from-to)1-13
Number of pages13
JournalGenes
Volume11
Issue number7
DOIs
StatePublished - Jul 2020

Keywords

  • COX-2 inhibitor
  • Chemoprevention
  • MPNST
  • Malignancy
  • Mebendazole (MBZ)
  • Neurofibromatosis 1 (NF1)
  • Sarcoma

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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