Prevalence of unsuspected abnormal echocardiograms in adolescents with down syndrome

Sarah B. Clauss; Samuel S. Gidding; Claire I. Cochrane; Rachel Walega; Babette S. Zemel; Mary E. Pipan; Sheela N. Magge; Andrea Kelly; Meryl S. Cohen

doi:10.1002/ajmg.a.61367

Prevalence of unsuspected abnormal echocardiograms in adolescents with down syndrome

Sarah B. Clauss, Samuel S. Gidding, Claire I. Cochrane, Rachel Walega, Babette S. Zemel, Mary E. Pipan, Sheela N. Magge, Andrea Kelly, Meryl S. Cohen

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The purpose of this article is to describe the prevalence of cardiac disease previously undiagnosed in healthy asymptomatic children and adolescents with Down syndrome (DS). Subjects with DS ages 10–20 years were recruited from two sites, the Children's Hospital of Philadelphia (Philadelphia, PA) and Children's National Health System (Washington, DC) for a cross-sectional study of body composition and cardiometabolic risk. Echocardiographic and clinical data were collected from patients enrolled in the parent study of cardiometabolic risk. Nine (6%) new cardiac diagnoses were identified out of 149 eligible patients. All new findings resulted in outpatient referrals to pediatric cardiology. Current guidelines recommend screening all newborns with DS for congenital heart disease. Older patients with DS may benefit from rescreening.

Original language	English (US)
Pages (from-to)	2420-2424
Number of pages	5
Journal	American Journal of Medical Genetics, Part A
Volume	179
Issue number	12
DOIs	https://doi.org/10.1002/ajmg.a.61367
State	Published - Dec 1 2019
Externally published	Yes

Keywords

Down syndrome
congenital heart disease
echocardiogram

ASJC Scopus subject areas

Genetics
Genetics(clinical)

Access to Document

10.1002/ajmg.a.61367

Cite this

@article{55b5b399ea274dd4bc3297ce4f16dead,

title = "Prevalence of unsuspected abnormal echocardiograms in adolescents with down syndrome",

abstract = "The purpose of this article is to describe the prevalence of cardiac disease previously undiagnosed in healthy asymptomatic children and adolescents with Down syndrome (DS). Subjects with DS ages 10–20 years were recruited from two sites, the Children's Hospital of Philadelphia (Philadelphia, PA) and Children's National Health System (Washington, DC) for a cross-sectional study of body composition and cardiometabolic risk. Echocardiographic and clinical data were collected from patients enrolled in the parent study of cardiometabolic risk. Nine (6%) new cardiac diagnoses were identified out of 149 eligible patients. All new findings resulted in outpatient referrals to pediatric cardiology. Current guidelines recommend screening all newborns with DS for congenital heart disease. Older patients with DS may benefit from rescreening.",

keywords = "Down syndrome, congenital heart disease, echocardiogram",

author = "Clauss, {Sarah B.} and Gidding, {Samuel S.} and Cochrane, {Claire I.} and Rachel Walega and Zemel, {Babette S.} and Pipan, {Mary E.} and Magge, {Sheela N.} and Andrea Kelly and Cohen, {Meryl S.}",

note = "Publisher Copyright: {\textcopyright} 2019 Wiley Periodicals, Inc.",

year = "2019",

month = dec,

day = "1",

doi = "10.1002/ajmg.a.61367",

language = "English (US)",

volume = "179",

pages = "2420--2424",

journal = "American Journal of Medical Genetics, Part A",

issn = "1552-4825",

publisher = "Wiley-Liss Inc.",

number = "12",

}

TY - JOUR

T1 - Prevalence of unsuspected abnormal echocardiograms in adolescents with down syndrome

AU - Clauss, Sarah B.

AU - Gidding, Samuel S.

AU - Cochrane, Claire I.

AU - Walega, Rachel

AU - Zemel, Babette S.

AU - Pipan, Mary E.

AU - Magge, Sheela N.

AU - Kelly, Andrea

AU - Cohen, Meryl S.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - The purpose of this article is to describe the prevalence of cardiac disease previously undiagnosed in healthy asymptomatic children and adolescents with Down syndrome (DS). Subjects with DS ages 10–20 years were recruited from two sites, the Children's Hospital of Philadelphia (Philadelphia, PA) and Children's National Health System (Washington, DC) for a cross-sectional study of body composition and cardiometabolic risk. Echocardiographic and clinical data were collected from patients enrolled in the parent study of cardiometabolic risk. Nine (6%) new cardiac diagnoses were identified out of 149 eligible patients. All new findings resulted in outpatient referrals to pediatric cardiology. Current guidelines recommend screening all newborns with DS for congenital heart disease. Older patients with DS may benefit from rescreening.

AB - The purpose of this article is to describe the prevalence of cardiac disease previously undiagnosed in healthy asymptomatic children and adolescents with Down syndrome (DS). Subjects with DS ages 10–20 years were recruited from two sites, the Children's Hospital of Philadelphia (Philadelphia, PA) and Children's National Health System (Washington, DC) for a cross-sectional study of body composition and cardiometabolic risk. Echocardiographic and clinical data were collected from patients enrolled in the parent study of cardiometabolic risk. Nine (6%) new cardiac diagnoses were identified out of 149 eligible patients. All new findings resulted in outpatient referrals to pediatric cardiology. Current guidelines recommend screening all newborns with DS for congenital heart disease. Older patients with DS may benefit from rescreening.

KW - Down syndrome

KW - congenital heart disease

KW - echocardiogram

UR - http://www.scopus.com/inward/record.url?scp=85073966327&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073966327&partnerID=8YFLogxK

U2 - 10.1002/ajmg.a.61367

DO - 10.1002/ajmg.a.61367

M3 - Article

C2 - 31588666

AN - SCOPUS:85073966327

SN - 1552-4825

VL - 179

SP - 2420

EP - 2424

JO - American Journal of Medical Genetics, Part A

JF - American Journal of Medical Genetics, Part A

IS - 12

ER -

Prevalence of unsuspected abnormal echocardiograms in adolescents with down syndrome

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this