TY - JOUR
T1 - Prevalence of sexually transmitted diseases and risk behaviors from the NIMH collaborative HIV/STD prevention trial
AU - Celentano, David D.
AU - Mayer, Kenneth H.
AU - Pequegnat, Willo
AU - Abdala, Nadia
AU - Green, Annette M.
AU - Handsfield, H. Hunter
AU - Hartwell, Tyler D.
N1 - Funding Information:
David D. Celentano, ScD, MHS, Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD. Kenneth H. Mayer, MD, Miriam Hospital/Brown University Medical School, Providence, RI. Willo Pequegnat, PhD, Associate Director, International AIDS Prevention Research, Center for Mental Health Research on AIDS, National Institute of Mental Health, Bethesda, MD. Nadia Abdala, DVM, PhD, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT. Annette M. Green, MPH, Research Triangle Institute International, Durham, NC. H. Hunter Handsfield, MD, Battelle Centers for Public Health Research and Evaluation, Seattle, WA. Tyler D. Hartwell, PhD, Research Triangle Institute International, Durham, NC. The National Institute of Mental Health Collaborative HIV/STD Prevention Trial Group∗ Address correspondence to: Willo Pequegnat, PhD, International AIDS Prevention Research, Center for Mental Health Research on AIDS, National Institute of Mental Health, NIH, 6001 Executive Boulevard, Room 6219, MSC 9619, Bethesda, MD, 20892. E-mail: wpequegn@mail.nih.gov This study was supported by the National Institute of Mental Health (NIMH) through the Cooperative Agreement mechanism (U10MH061499, U10MH061513, U10MH061536, U10MH061537, U10MH061543, U10MH061544). We would also like to acknowledge all of those who participated in and staffed the NIMH Collaborative HIV/STD Prevention Trial. ∗The NIMH Collaborative HIV/STD Prevention Trial Group+: Research Steering Committee/Site Principal Investigators and NIMH Senior Scientist: Carlos F. Caceres, MD, PhD (Cayetano Heredia University [UPCH]); David D. Celentano, ScD (Johns Hopkins University); Thomas J. Coates, PhD (David Geffen School of Medicine, University of California, Los Angeles [UCLA]); Tyler D. Hartwell, PhD (Research Triangle Institute International); Danuta Kasprzyk, PhD (Battelle); Jeffrey A. Kelly, PhD (Medical College of Wisconsin); Andrei P. Kozlov, PhD (Biomedical Center, St. Petersburg State University); Willo Pequegnat, PhD (National Institute of Mental Health); Mary Jane Rotheram-Borus, PhD (UCLA); Suniti Solomon, MD (Center for AIDS Research and Education [YRG CARE]); Godfrey Woelk, PhD (University of Zimbabwe Medical School); Zunyou Wu, PhD (Chinese Center for Disease Control and Prevention). Collaborating Scientists/Co-Investigators: Roman Dyatlov, PhD (Biomedical Center, St. Petersburg State University); A. K. Ganesh, ACA, BCom (YRG CARE); Li Li, PhD (UCLA); Sudha Sivaram, PhD, MPH (Johns Hopkins University); Anton M. Somlai, EdD (Medical College of Wisconsin). Assessment Workgroup: Eric G. Benotsch, PhD (Medical College of Wisconsin); Juliana Granskaya, PhD (St. Petersburg State University; The Biomedical Center); Jihui Guan, MD (Fujian Center for Disease Control and Prevention); Martha Lee, PhD (UCLA); Daniel E. MontaZo, PhD (Battelle). Biologic Outcomes Workgroup: Nadia Abdala, PhD (Yale University); Roger Detels, MD, MS (UCLA); David Katzenstein, MD (Stanford); Jeffrey Klausner, MD, MPH (San Francisco Department of Public Health,
PY - 2010/10
Y1 - 2010/10
N2 - This cross-sectional study describes the baseline prevalence and correlates of common bacterial and viral sexually transmitted diseases (STDs) and risk behaviors among individuals at high risk for HIV recruited in five low and middle-income countries. Correlations of risk behaviors and demographic factors with prevalent STDs and the association of STDs with HIV prevalence are examined. Between 2,212 and 5,543 participants were recruited in each of five countries (China, India, Peru, Russia, and Zimbabwe). Standard protocols were used to collect behavioral risk information and biological samples for STD testing. Risk factors for HIV/STD prevalence were evaluated using logistic regression models. STD prevalence was significantly higher for women than men in all countries, and the most prevalent STD was Herpes simplex virus-type 2 (HSV-2). HIV prevalence was generally low (below 5%)except in Zimbabwe (30% among women, 11.7% among men).Prevalence of bacterial STDs was generally low (below 5% for gonorrhea and under 7% for syphilis in all sites), with the exception of syphilis among female sex workers in India. Behavioral and demographic risks for STDs varied widely across the five study sites. Common risks for STDs included female gender, increasing number of recent sex partners, and in some sites, older age, particularly for chronic STDs (i.e., HSV-2 and HIV). Prevalence of HIV was not associated with STDs except in Zimbabwe, which showed a modest correlation between HIV and HSV-2 prevalence (Pearson coefficient =.55). These findings underscore the heterogeneity of global STD and HIV epidemics and suggest that local, focused interventions are needed to achieve significant declines in these infections.
AB - This cross-sectional study describes the baseline prevalence and correlates of common bacterial and viral sexually transmitted diseases (STDs) and risk behaviors among individuals at high risk for HIV recruited in five low and middle-income countries. Correlations of risk behaviors and demographic factors with prevalent STDs and the association of STDs with HIV prevalence are examined. Between 2,212 and 5,543 participants were recruited in each of five countries (China, India, Peru, Russia, and Zimbabwe). Standard protocols were used to collect behavioral risk information and biological samples for STD testing. Risk factors for HIV/STD prevalence were evaluated using logistic regression models. STD prevalence was significantly higher for women than men in all countries, and the most prevalent STD was Herpes simplex virus-type 2 (HSV-2). HIV prevalence was generally low (below 5%)except in Zimbabwe (30% among women, 11.7% among men).Prevalence of bacterial STDs was generally low (below 5% for gonorrhea and under 7% for syphilis in all sites), with the exception of syphilis among female sex workers in India. Behavioral and demographic risks for STDs varied widely across the five study sites. Common risks for STDs included female gender, increasing number of recent sex partners, and in some sites, older age, particularly for chronic STDs (i.e., HSV-2 and HIV). Prevalence of HIV was not associated with STDs except in Zimbabwe, which showed a modest correlation between HIV and HSV-2 prevalence (Pearson coefficient =.55). These findings underscore the heterogeneity of global STD and HIV epidemics and suggest that local, focused interventions are needed to achieve significant declines in these infections.
KW - Behavioral risk factors
KW - HIV prevention
KW - International
KW - Sexually transmitted diseases
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U2 - 10.1080/19317611.2010.494092
DO - 10.1080/19317611.2010.494092
M3 - Article
C2 - 25400718
AN - SCOPUS:78649999989
SN - 1931-7611
VL - 22
SP - 272
EP - 284
JO - International Journal of Sexual Health
JF - International Journal of Sexual Health
IS - 4
ER -