TY - JOUR
T1 - Prevalence of respiratory syncytial virus infection among hospitalized children presenting with acute lower respiratory tract infections
AU - Gupta, Soham
AU - Shamsundar, Ranjani
AU - Shet, Anita
AU - Chawan, Rashmi
AU - Srinivasa, Hiresave
N1 - Funding Information:
Role of Funding Source Funding for the study was provided by Indian Council of Medical Research (ICMR) under PC-11028.
Funding Information:
Acknowledgements The authors thank the staff of the Department of Pediatrics, St. John’s Medical College Hospital, Bangalore, for their constant support and assistance. This study was supported by grants from Indian Council of Medical Research (ICMR; PC#11028)
Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2011/12
Y1 - 2011/12
N2 - Objective To evaluate the prevalence of RSV among hospitalized young children presenting with ALRI in Bangalore, India. Methods Respiratory syncytial virus (RSV) antigen detection was performed by direct fluorescent antibody (DFA) staining on 77 nasopharyngeal wash samples collected from hospitalized children below 2 years of age with a diagnosis of acute lower respiratory tract infection (ALRI). Results Out of 77 samples tested for RSV with DFA, 17 (22.1%) were found RSV-positive with a mean age of 8.24± 7.21 months (M:F=1.8:1). Three children had congenital cardiac disease and one child had a history of prematurity. One child had re-infection within one month of primary infection. RSV-infected children were more likely to have a diagnosis of bronchiolitis than RSV-negative children (p<0.001). Conclusions RSVinfection is a significant cause ofmorbidity among children presenting with ALRI in southern India. In resource-limited settings, DFA can be used as an important tool for rapid detection of RSV and can potentially eliminate prolonged hospitalization and unnecessary use of antibiotics.
AB - Objective To evaluate the prevalence of RSV among hospitalized young children presenting with ALRI in Bangalore, India. Methods Respiratory syncytial virus (RSV) antigen detection was performed by direct fluorescent antibody (DFA) staining on 77 nasopharyngeal wash samples collected from hospitalized children below 2 years of age with a diagnosis of acute lower respiratory tract infection (ALRI). Results Out of 77 samples tested for RSV with DFA, 17 (22.1%) were found RSV-positive with a mean age of 8.24± 7.21 months (M:F=1.8:1). Three children had congenital cardiac disease and one child had a history of prematurity. One child had re-infection within one month of primary infection. RSV-infected children were more likely to have a diagnosis of bronchiolitis than RSV-negative children (p<0.001). Conclusions RSVinfection is a significant cause ofmorbidity among children presenting with ALRI in southern India. In resource-limited settings, DFA can be used as an important tool for rapid detection of RSV and can potentially eliminate prolonged hospitalization and unnecessary use of antibiotics.
KW - Acute lower respiratory tract infections (ALRTI)
KW - Direct fluorescent antibody staining (DFA)
KW - Epidemiology Introduction
KW - Respiratory syncytial virus (RSV)
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U2 - 10.1007/s12098-011-0491-0
DO - 10.1007/s12098-011-0491-0
M3 - Article
C2 - 21660398
AN - SCOPUS:84857050413
SN - 0019-5456
VL - 78
SP - 1495
EP - 1497
JO - Indian journal of pediatrics
JF - Indian journal of pediatrics
IS - 12
ER -