Prevalence of ras gene mutations in human colorectal cancers

Johannes L. Bos; Matty Verlaan de Vries; Alex J. Van Der Eb; Eric R. Fearon; Bert Vogelstein; Stanley R. Hamilton; Jacques H. Van Boom

doi:10.1038/327293a0

Prevalence of ras gene mutations in human colorectal cancers

Johannes L. Bos, Matty Verlaan de Vries, Alex J. Van Der Eb, Eric R. Fearon, Bert Vogelstein, Stanley R. Hamilton, Jacques H. Van Boom

School of Medicine

Research output: Contribution to journal › Article › peer-review

1547 Scopus citations

Abstract

A combination of DNA hybridization analyses and tissue sectioning techniques demonstrate that ras gene mutations occur in over a third of human colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that the mutations usually precede the development of malignancy.

Original language	English (US)
Pages (from-to)	293-297
Number of pages	5
Journal	Nature
Volume	327
Issue number	6120
DOIs	https://doi.org/10.1038/327293a0
State	Published - 1987

ASJC Scopus subject areas

General

Access to Document

10.1038/327293a0

Cite this

@article{d78ae7f3ae5143be98efb0209c92332f,

title = "Prevalence of ras gene mutations in human colorectal cancers",

abstract = "A combination of DNA hybridization analyses and tissue sectioning techniques demonstrate that ras gene mutations occur in over a third of human colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that the mutations usually precede the development of malignancy.",

author = "Bos, {Johannes L.} and Vries, {Matty Verlaan de} and {Van Der Eb}, {Alex J.} and Fearon, {Eric R.} and Bert Vogelstein and Hamilton, {Stanley R.} and {Van Boom}, {Jacques H.}",

year = "1987",

doi = "10.1038/327293a0",

language = "English (US)",

volume = "327",

pages = "293--297",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Publishing Group",

number = "6120",

}

TY - JOUR

T1 - Prevalence of ras gene mutations in human colorectal cancers

AU - Bos, Johannes L.

AU - Vries, Matty Verlaan de

AU - Van Der Eb, Alex J.

AU - Fearon, Eric R.

AU - Vogelstein, Bert

AU - Hamilton, Stanley R.

AU - Van Boom, Jacques H.

PY - 1987

Y1 - 1987

N2 - A combination of DNA hybridization analyses and tissue sectioning techniques demonstrate that ras gene mutations occur in over a third of human colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that the mutations usually precede the development of malignancy.

AB - A combination of DNA hybridization analyses and tissue sectioning techniques demonstrate that ras gene mutations occur in over a third of human colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that the mutations usually precede the development of malignancy.

UR - http://www.scopus.com/inward/record.url?scp=0023256456&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023256456&partnerID=8YFLogxK

U2 - 10.1038/327293a0

DO - 10.1038/327293a0

M3 - Article

C2 - 3587348

AN - SCOPUS:0023256456

SN - 0028-0836

VL - 327

SP - 293

EP - 297

JO - Nature

JF - Nature

IS - 6120

ER -

Prevalence of ras gene mutations in human colorectal cancers

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this