Prevalence of ras gene mutations in human colorectal cancers

Johannes L. Bos, Matty Verlaan de Vries, Alex J. Van Der Eb, Eric R. Fearon, Bert Vogelstein, Stanley R. Hamilton, Jacques H. Van Boom

Research output: Contribution to journalArticlepeer-review

1547 Scopus citations


A combination of DNA hybridization analyses and tissue sectioning techniques demonstrate that ras gene mutations occur in over a third of human colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that the mutations usually precede the development of malignancy.

Original languageEnglish (US)
Pages (from-to)293-297
Number of pages5
Issue number6120
StatePublished - 1987

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Prevalence of ras gene mutations in human colorectal cancers'. Together they form a unique fingerprint.

Cite this