Prevalence of ras gene mutations in human colorectal cancers

Johannes L. Bos, Matty Verlaan de Vries, Alex J. Van Der Eb, Eric R. Fearon, Bert Vogelstein, Stanley R. Hamilton, Jacques H. Van Boom

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Abstract

A combination of DNA hybridization analyses and tissue sectioning techniques demonstrate that ras gene mutations occur in over a third of human colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that the mutations usually precede the development of malignancy.

Original languageEnglish (US)
Pages (from-to)293-297
Number of pages5
JournalNature
Volume327
Issue number6120
DOIs
StatePublished - Jan 1 1987

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Cite this

Bos, J. L., Vries, M. V. D., Van Der Eb, A. J., Fearon, E. R., Vogelstein, B., Hamilton, S. R., & Van Boom, J. H. (1987). Prevalence of ras gene mutations in human colorectal cancers. Nature, 327(6120), 293-297. https://doi.org/10.1038/327293a0