TY - JOUR
T1 - Prevalence of Orofacial Clefts among Live Births in China
T2 - A Systematic Review and Meta-Analysis
AU - Wang, Mengying
AU - Yuan, Yuan
AU - Wang, Zifan
AU - Liu, Dongjing
AU - Wang, Zhuqing
AU - Sun, Feng
AU - Wang, Ping
AU - Zhu, Hongping
AU - Li, Jing
AU - Wu, Tao
AU - Beaty, Terri H.
N1 - Publisher Copyright:
© 2017 Wiley Periodicals, Inc.
PY - 2017/7/17
Y1 - 2017/7/17
N2 - Background: Orofacial clefts (OFCs) are common human birth defects in China. However, studies on the prevalence of OFCs present inconsistent results. The overall prevalence and geographic distribution of OFCs are poorly described in China. Thus, we conducted a systematic review and meta-analysis to estimate the prevalence of OFCs. Methods: The systematic review and meta-analysis were conducted on the basis of an established protocol (PROSPERO 2015: CRD42015030198). We systematically searched for articles in four electronic databases, including Embase, PubMed, Wanfang Database, and China National Knowledge Infrastructure (CNKI) to identify relevant studies about prevalence of OFCs in China. Meta-analysis, including subgroup analysis, was conducted to estimate the pooled prevalence. Results: A total of 41 studies published between 1986 and 2015 were included in our analysis. The sample size ranged from 2,586 to 4,611,808 live births. The random-effects model of meta-analysis showed that the overall prevalence of OFCs in China was 1.4 per 1000 live births (95% confidence interval [CI], 1.1–1.7). In subgroup analysis based on geographic regions, we found that OFC prevalence in Southwest (2.3 per 1000 live births, 95% CI, 1.1–4.7) was higher than that in other regions of China. There were no significant time trends of OFCs during the study period (p-value = 0.47). Conclusion: The overall prevalence of OFCs in China was 1.4 per 1000 live births. No significant secular trend of prevalence has been found in this analysis. Further studies need to be conducted to explore the etiology of OFC to better control the risk of this common birth defect. Birth Defects Research 109:1011–1019, 2017.
AB - Background: Orofacial clefts (OFCs) are common human birth defects in China. However, studies on the prevalence of OFCs present inconsistent results. The overall prevalence and geographic distribution of OFCs are poorly described in China. Thus, we conducted a systematic review and meta-analysis to estimate the prevalence of OFCs. Methods: The systematic review and meta-analysis were conducted on the basis of an established protocol (PROSPERO 2015: CRD42015030198). We systematically searched for articles in four electronic databases, including Embase, PubMed, Wanfang Database, and China National Knowledge Infrastructure (CNKI) to identify relevant studies about prevalence of OFCs in China. Meta-analysis, including subgroup analysis, was conducted to estimate the pooled prevalence. Results: A total of 41 studies published between 1986 and 2015 were included in our analysis. The sample size ranged from 2,586 to 4,611,808 live births. The random-effects model of meta-analysis showed that the overall prevalence of OFCs in China was 1.4 per 1000 live births (95% confidence interval [CI], 1.1–1.7). In subgroup analysis based on geographic regions, we found that OFC prevalence in Southwest (2.3 per 1000 live births, 95% CI, 1.1–4.7) was higher than that in other regions of China. There were no significant time trends of OFCs during the study period (p-value = 0.47). Conclusion: The overall prevalence of OFCs in China was 1.4 per 1000 live births. No significant secular trend of prevalence has been found in this analysis. Further studies need to be conducted to explore the etiology of OFC to better control the risk of this common birth defect. Birth Defects Research 109:1011–1019, 2017.
KW - meta-analysis
KW - orofacial clefts
KW - prevalence
KW - systematic review
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U2 - 10.1002/bdr2.1043
DO - 10.1002/bdr2.1043
M3 - Review article
C2 - 28635078
AN - SCOPUS:85026647086
SN - 2472-1727
VL - 109
SP - 1011
EP - 1019
JO - Birth Defects Research
JF - Birth Defects Research
IS - 13
ER -