Prevalence of lower genital tract infections among human immunodeficiency virus (HIV)-seropositive and high-risk HIV-seronegative women

Susan Cu-Uvin, Joseph W. Hogan, Dora Warren, Robert S. Klein, Jeffrey Peipert, Paula Schuman, Scott Holmberg, Jean Anderson, Ellie Schoenbaum, David Vlahov, Kenneth H. Mayer

Research output: Contribution to journalArticle

Abstract

This study was undertaken to assess whether the prevalence of lower genital tract infections among human immunodeficiency virus (HIV)- seropositive women was higher than among high-risk HIV-seronegative women at their baseline visit for the HIV Epidemiology Research Study. Results were available for 851 HIV-seropositive and 434 HIV-seronegative women. Human papilloma virus (HPV) infection was more prevalent among HIV-seropositive women (64% vs. 28%). Bacterial vaginosis was common (35% vs. 33%), followed by trichomoniasis (12% vs. 10%), syphilis (8% vs. 6%), Chlamydia trachomatis infection (4% vs. 5%), candidal vaginitis (3% vs. 2%), and Neisseria gonorrhoeae infection (0.8% vs. 0.3%). Alcohol use (odds ratio [OR], 1.8; 95% confidence interval [CI], 1.3-2.4) and smoking (OR, 1.8; 95% CI, 1.3-2.5) were associated with bacterial vaginosis. Bacterial vaginosis (OR, 2.3; 95% CI, 1.5-3.4), trichomoniasis (OR, 2.3; 95% CI, 1.1-4.7), and syphilis (OR, 3.1; 95% CI, 1.3-7.4) were found to be more prevalent among black women. Our study showed no statistically significant difference in the prevalence of lower genital tract infections except for HPV between HIV-infected and demographically and behaviorally similar HIV-uninfected high-risk women.

Original languageEnglish (US)
Pages (from-to)1145-1150
Number of pages6
JournalClinical Infectious Diseases
Volume29
Issue number5
DOIs
StatePublished - 1999

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Reproductive Tract Infections
HIV
Bacterial Vaginosis
Papillomaviridae
Odds Ratio
Confidence Intervals
Syphilis
Vaginitis
Chlamydia Infections
Neisseria gonorrhoeae
Chlamydia trachomatis
Virus Diseases
Epidemiology
Smoking
Alcohols

ASJC Scopus subject areas

  • Immunology

Cite this

Prevalence of lower genital tract infections among human immunodeficiency virus (HIV)-seropositive and high-risk HIV-seronegative women. / Cu-Uvin, Susan; Hogan, Joseph W.; Warren, Dora; Klein, Robert S.; Peipert, Jeffrey; Schuman, Paula; Holmberg, Scott; Anderson, Jean; Schoenbaum, Ellie; Vlahov, David; Mayer, Kenneth H.

In: Clinical Infectious Diseases, Vol. 29, No. 5, 1999, p. 1145-1150.

Research output: Contribution to journalArticle

Cu-Uvin, S, Hogan, JW, Warren, D, Klein, RS, Peipert, J, Schuman, P, Holmberg, S, Anderson, J, Schoenbaum, E, Vlahov, D & Mayer, KH 1999, 'Prevalence of lower genital tract infections among human immunodeficiency virus (HIV)-seropositive and high-risk HIV-seronegative women', Clinical Infectious Diseases, vol. 29, no. 5, pp. 1145-1150. https://doi.org/10.1086/313434
Cu-Uvin, Susan ; Hogan, Joseph W. ; Warren, Dora ; Klein, Robert S. ; Peipert, Jeffrey ; Schuman, Paula ; Holmberg, Scott ; Anderson, Jean ; Schoenbaum, Ellie ; Vlahov, David ; Mayer, Kenneth H. / Prevalence of lower genital tract infections among human immunodeficiency virus (HIV)-seropositive and high-risk HIV-seronegative women. In: Clinical Infectious Diseases. 1999 ; Vol. 29, No. 5. pp. 1145-1150.
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