Prevalence of hypercholesterolemia among siblings of persons with premature coronary heart disease

Application of the second adult treatment panel guidelines

Jerilyn K. Allen, Deborah Rohm Young, Roger S Blumenthal, Taryn F. Moy, Lisa Yanek, Lora Wilder, Lewis Becker, Diane M Becker

Research output: Contribution to journalArticle

Abstract

Background: Increased blood cholesterol, specifically high low-density lipoprotein cholesterol, increases risk for coronary heart disease (CHD). Persons with a positive family history of premature CHD also are at markedly increased risk. Objective: To examine the prevalence of hypercholesterolemia based on the second report of the National Cholesterol Educational Program Adult Treatment Panel (ATP II) guidelines in the asymptomatic healthy siblings of people with premature CHD. Methods: A total of 668 asymptomatic healthy siblings (354 men and 314 women) underwent screening for risk factors for CHD. Siblings were categorized into treatment categories for primary prevention defined by ATP II. The percentage who were candidates for intervention were compared with the published national estimates for those without CHD from the third National Health and Nutrition Examination Survey (NHANES III). Results: Based on ATP II guidelines, 65% of the asymptomatic adult siblings required fasting lipoprotein analysis compared with 33% of adults without CHD in the national reference population. Of the siblings who met the criteria for fasting lipoprotein analysis, most (56%) were candidates for dietary therapy, more than twice the proportion of adults from NHANES III. The percentage of the siblings who qualified for drug intervention and dietary therapy was 3 times greater than the national sample, 33% vs 11%, respectively. Assuming a 10% hypothetical reduction in low-density lipoprotein cholesterol levels as the result of dietary modification, the proportion of the sibling sample who were possible candidates for drug therapy was 20%, still 4 times that predicted for the national sample. Conclusions: These results underscore the need for aggressive detection and treatment of hypercholesterolemia in this easily identifiable high-risk population of siblings of people with premature CHD.

Original languageEnglish (US)
Pages (from-to)1654-1660
Number of pages7
JournalArchives of Internal Medicine
Volume156
Issue number15
DOIs
StatePublished - Aug 12 1996

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Hypercholesterolemia
Coronary Disease
Siblings
Guidelines
Nutrition Surveys
Adenosine Triphosphate
Therapeutics
LDL Cholesterol
Lipoproteins
Fasting
Cholesterol
Diet Therapy
Primary Prevention
HDL Cholesterol
Population
Drug Therapy
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Internal Medicine

Cite this

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title = "Prevalence of hypercholesterolemia among siblings of persons with premature coronary heart disease: Application of the second adult treatment panel guidelines",
abstract = "Background: Increased blood cholesterol, specifically high low-density lipoprotein cholesterol, increases risk for coronary heart disease (CHD). Persons with a positive family history of premature CHD also are at markedly increased risk. Objective: To examine the prevalence of hypercholesterolemia based on the second report of the National Cholesterol Educational Program Adult Treatment Panel (ATP II) guidelines in the asymptomatic healthy siblings of people with premature CHD. Methods: A total of 668 asymptomatic healthy siblings (354 men and 314 women) underwent screening for risk factors for CHD. Siblings were categorized into treatment categories for primary prevention defined by ATP II. The percentage who were candidates for intervention were compared with the published national estimates for those without CHD from the third National Health and Nutrition Examination Survey (NHANES III). Results: Based on ATP II guidelines, 65{\%} of the asymptomatic adult siblings required fasting lipoprotein analysis compared with 33{\%} of adults without CHD in the national reference population. Of the siblings who met the criteria for fasting lipoprotein analysis, most (56{\%}) were candidates for dietary therapy, more than twice the proportion of adults from NHANES III. The percentage of the siblings who qualified for drug intervention and dietary therapy was 3 times greater than the national sample, 33{\%} vs 11{\%}, respectively. Assuming a 10{\%} hypothetical reduction in low-density lipoprotein cholesterol levels as the result of dietary modification, the proportion of the sibling sample who were possible candidates for drug therapy was 20{\%}, still 4 times that predicted for the national sample. Conclusions: These results underscore the need for aggressive detection and treatment of hypercholesterolemia in this easily identifiable high-risk population of siblings of people with premature CHD.",
author = "Allen, {Jerilyn K.} and Young, {Deborah Rohm} and Blumenthal, {Roger S} and Moy, {Taryn F.} and Lisa Yanek and Lora Wilder and Lewis Becker and Becker, {Diane M}",
year = "1996",
month = "8",
day = "12",
doi = "10.1001/archinte.156.15.1654",
language = "English (US)",
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pages = "1654--1660",
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TY - JOUR

T1 - Prevalence of hypercholesterolemia among siblings of persons with premature coronary heart disease

T2 - Application of the second adult treatment panel guidelines

AU - Allen, Jerilyn K.

AU - Young, Deborah Rohm

AU - Blumenthal, Roger S

AU - Moy, Taryn F.

AU - Yanek, Lisa

AU - Wilder, Lora

AU - Becker, Lewis

AU - Becker, Diane M

PY - 1996/8/12

Y1 - 1996/8/12

N2 - Background: Increased blood cholesterol, specifically high low-density lipoprotein cholesterol, increases risk for coronary heart disease (CHD). Persons with a positive family history of premature CHD also are at markedly increased risk. Objective: To examine the prevalence of hypercholesterolemia based on the second report of the National Cholesterol Educational Program Adult Treatment Panel (ATP II) guidelines in the asymptomatic healthy siblings of people with premature CHD. Methods: A total of 668 asymptomatic healthy siblings (354 men and 314 women) underwent screening for risk factors for CHD. Siblings were categorized into treatment categories for primary prevention defined by ATP II. The percentage who were candidates for intervention were compared with the published national estimates for those without CHD from the third National Health and Nutrition Examination Survey (NHANES III). Results: Based on ATP II guidelines, 65% of the asymptomatic adult siblings required fasting lipoprotein analysis compared with 33% of adults without CHD in the national reference population. Of the siblings who met the criteria for fasting lipoprotein analysis, most (56%) were candidates for dietary therapy, more than twice the proportion of adults from NHANES III. The percentage of the siblings who qualified for drug intervention and dietary therapy was 3 times greater than the national sample, 33% vs 11%, respectively. Assuming a 10% hypothetical reduction in low-density lipoprotein cholesterol levels as the result of dietary modification, the proportion of the sibling sample who were possible candidates for drug therapy was 20%, still 4 times that predicted for the national sample. Conclusions: These results underscore the need for aggressive detection and treatment of hypercholesterolemia in this easily identifiable high-risk population of siblings of people with premature CHD.

AB - Background: Increased blood cholesterol, specifically high low-density lipoprotein cholesterol, increases risk for coronary heart disease (CHD). Persons with a positive family history of premature CHD also are at markedly increased risk. Objective: To examine the prevalence of hypercholesterolemia based on the second report of the National Cholesterol Educational Program Adult Treatment Panel (ATP II) guidelines in the asymptomatic healthy siblings of people with premature CHD. Methods: A total of 668 asymptomatic healthy siblings (354 men and 314 women) underwent screening for risk factors for CHD. Siblings were categorized into treatment categories for primary prevention defined by ATP II. The percentage who were candidates for intervention were compared with the published national estimates for those without CHD from the third National Health and Nutrition Examination Survey (NHANES III). Results: Based on ATP II guidelines, 65% of the asymptomatic adult siblings required fasting lipoprotein analysis compared with 33% of adults without CHD in the national reference population. Of the siblings who met the criteria for fasting lipoprotein analysis, most (56%) were candidates for dietary therapy, more than twice the proportion of adults from NHANES III. The percentage of the siblings who qualified for drug intervention and dietary therapy was 3 times greater than the national sample, 33% vs 11%, respectively. Assuming a 10% hypothetical reduction in low-density lipoprotein cholesterol levels as the result of dietary modification, the proportion of the sibling sample who were possible candidates for drug therapy was 20%, still 4 times that predicted for the national sample. Conclusions: These results underscore the need for aggressive detection and treatment of hypercholesterolemia in this easily identifiable high-risk population of siblings of people with premature CHD.

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