Prevalence of HTLV-III/LAV in Household Contacts of Patients With Confirmed AIDS and Controls in Kinshasa, Zaire

Jonathan M. Mann, Thomas C Quinn, Henry Francis, Nzila Nzilambi, Ngaly Bosenge, Kapita Bila, Joseph B. McCormick, Kalisa Ruti, Pangu Kaza Asila, James W. Curran

Research output: Contribution to journalArticle

Abstract

Household members of 46 patients with confirmed acquired immunodeficiency syndrome (AIDS) and 43 human T-cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV)-seronegative controls from Kinshasa, Zaire, were identified and sought for serologic testing for evidence of HTLV-III/LAV infection. Twenty (9.8%) of 204 case-household members and three (1.9%) of 155 control-household members were HTLV-III/LAV seropositive (relative risk=5.1; 95% confidence interval, 1.7 to 15.2). Eleven (61.1%) of 18 spouses of patients with AIDS were HTLV-III/LAV seropositive, compared with one (3.7%) of 27 control spouses (relative risk=16.5; 95% confidence interval, 3.7 to 75.0). Except for spouses, the rate of HTLV-III/LAV seropositivity did not differ significantly between case and control households. Furthermore, for adults in case households who were not spouses, the number seropositive for HTLV-III/LAV was identical to that predicted from sex- and age-specific HTLV-III/LAV seroprevalence rates. These data from Zaire confirm the results of US and European studies of household contacts of infected hemophiliacs and pediatric patients with AIDS.

Original languageEnglish (US)
Pages (from-to)721-724
Number of pages4
JournalJournal of the American Medical Association
Volume256
Issue number6
DOIs
StatePublished - Aug 8 1986
Externally publishedYes

Fingerprint

Democratic Republic of the Congo
Acquired Immunodeficiency Syndrome
HIV
Spouses
Confidence Intervals
Seroepidemiologic Studies
Virus Diseases

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Prevalence of HTLV-III/LAV in Household Contacts of Patients With Confirmed AIDS and Controls in Kinshasa, Zaire. / Mann, Jonathan M.; Quinn, Thomas C; Francis, Henry; Nzilambi, Nzila; Bosenge, Ngaly; Bila, Kapita; McCormick, Joseph B.; Ruti, Kalisa; Asila, Pangu Kaza; Curran, James W.

In: Journal of the American Medical Association, Vol. 256, No. 6, 08.08.1986, p. 721-724.

Research output: Contribution to journalArticle

Mann, JM, Quinn, TC, Francis, H, Nzilambi, N, Bosenge, N, Bila, K, McCormick, JB, Ruti, K, Asila, PK & Curran, JW 1986, 'Prevalence of HTLV-III/LAV in Household Contacts of Patients With Confirmed AIDS and Controls in Kinshasa, Zaire', Journal of the American Medical Association, vol. 256, no. 6, pp. 721-724. https://doi.org/10.1001/jama.1986.03380060047023
Mann, Jonathan M. ; Quinn, Thomas C ; Francis, Henry ; Nzilambi, Nzila ; Bosenge, Ngaly ; Bila, Kapita ; McCormick, Joseph B. ; Ruti, Kalisa ; Asila, Pangu Kaza ; Curran, James W. / Prevalence of HTLV-III/LAV in Household Contacts of Patients With Confirmed AIDS and Controls in Kinshasa, Zaire. In: Journal of the American Medical Association. 1986 ; Vol. 256, No. 6. pp. 721-724.
@article{f741691a3bcf4543ad8a1a512f884bb5,
title = "Prevalence of HTLV-III/LAV in Household Contacts of Patients With Confirmed AIDS and Controls in Kinshasa, Zaire",
abstract = "Household members of 46 patients with confirmed acquired immunodeficiency syndrome (AIDS) and 43 human T-cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV)-seronegative controls from Kinshasa, Zaire, were identified and sought for serologic testing for evidence of HTLV-III/LAV infection. Twenty (9.8{\%}) of 204 case-household members and three (1.9{\%}) of 155 control-household members were HTLV-III/LAV seropositive (relative risk=5.1; 95{\%} confidence interval, 1.7 to 15.2). Eleven (61.1{\%}) of 18 spouses of patients with AIDS were HTLV-III/LAV seropositive, compared with one (3.7{\%}) of 27 control spouses (relative risk=16.5; 95{\%} confidence interval, 3.7 to 75.0). Except for spouses, the rate of HTLV-III/LAV seropositivity did not differ significantly between case and control households. Furthermore, for adults in case households who were not spouses, the number seropositive for HTLV-III/LAV was identical to that predicted from sex- and age-specific HTLV-III/LAV seroprevalence rates. These data from Zaire confirm the results of US and European studies of household contacts of infected hemophiliacs and pediatric patients with AIDS.",
author = "Mann, {Jonathan M.} and Quinn, {Thomas C} and Henry Francis and Nzila Nzilambi and Ngaly Bosenge and Kapita Bila and McCormick, {Joseph B.} and Kalisa Ruti and Asila, {Pangu Kaza} and Curran, {James W.}",
year = "1986",
month = "8",
day = "8",
doi = "10.1001/jama.1986.03380060047023",
language = "English (US)",
volume = "256",
pages = "721--724",
journal = "JAMA - Journal of the American Medical Association",
issn = "0098-7484",
publisher = "American Medical Association",
number = "6",

}

TY - JOUR

T1 - Prevalence of HTLV-III/LAV in Household Contacts of Patients With Confirmed AIDS and Controls in Kinshasa, Zaire

AU - Mann, Jonathan M.

AU - Quinn, Thomas C

AU - Francis, Henry

AU - Nzilambi, Nzila

AU - Bosenge, Ngaly

AU - Bila, Kapita

AU - McCormick, Joseph B.

AU - Ruti, Kalisa

AU - Asila, Pangu Kaza

AU - Curran, James W.

PY - 1986/8/8

Y1 - 1986/8/8

N2 - Household members of 46 patients with confirmed acquired immunodeficiency syndrome (AIDS) and 43 human T-cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV)-seronegative controls from Kinshasa, Zaire, were identified and sought for serologic testing for evidence of HTLV-III/LAV infection. Twenty (9.8%) of 204 case-household members and three (1.9%) of 155 control-household members were HTLV-III/LAV seropositive (relative risk=5.1; 95% confidence interval, 1.7 to 15.2). Eleven (61.1%) of 18 spouses of patients with AIDS were HTLV-III/LAV seropositive, compared with one (3.7%) of 27 control spouses (relative risk=16.5; 95% confidence interval, 3.7 to 75.0). Except for spouses, the rate of HTLV-III/LAV seropositivity did not differ significantly between case and control households. Furthermore, for adults in case households who were not spouses, the number seropositive for HTLV-III/LAV was identical to that predicted from sex- and age-specific HTLV-III/LAV seroprevalence rates. These data from Zaire confirm the results of US and European studies of household contacts of infected hemophiliacs and pediatric patients with AIDS.

AB - Household members of 46 patients with confirmed acquired immunodeficiency syndrome (AIDS) and 43 human T-cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV)-seronegative controls from Kinshasa, Zaire, were identified and sought for serologic testing for evidence of HTLV-III/LAV infection. Twenty (9.8%) of 204 case-household members and three (1.9%) of 155 control-household members were HTLV-III/LAV seropositive (relative risk=5.1; 95% confidence interval, 1.7 to 15.2). Eleven (61.1%) of 18 spouses of patients with AIDS were HTLV-III/LAV seropositive, compared with one (3.7%) of 27 control spouses (relative risk=16.5; 95% confidence interval, 3.7 to 75.0). Except for spouses, the rate of HTLV-III/LAV seropositivity did not differ significantly between case and control households. Furthermore, for adults in case households who were not spouses, the number seropositive for HTLV-III/LAV was identical to that predicted from sex- and age-specific HTLV-III/LAV seroprevalence rates. These data from Zaire confirm the results of US and European studies of household contacts of infected hemophiliacs and pediatric patients with AIDS.

UR - http://www.scopus.com/inward/record.url?scp=0022543298&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022543298&partnerID=8YFLogxK

U2 - 10.1001/jama.1986.03380060047023

DO - 10.1001/jama.1986.03380060047023

M3 - Article

C2 - 3014178

AN - SCOPUS:0022543298

VL - 256

SP - 721

EP - 724

JO - JAMA - Journal of the American Medical Association

JF - JAMA - Journal of the American Medical Association

SN - 0098-7484

IS - 6

ER -