Prevalence of HTLV-III/LAV in Household Contacts of Patients With Confirmed AIDS and Controls in Kinshasa, Zaire

Jonathan M. Mann, Thomas C. Quinn, Henry Francis, Nzila Nzilambi, Ngaly Bosenge, Kapita Bila, Joseph B. McCormick, Kalisa Ruti, Pangu Kaza Asila, James W. Curran

Research output: Contribution to journalArticle

Abstract

Household members of 46 patients with confirmed acquired immunodeficiency syndrome (AIDS) and 43 human T-cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV)-seronegative controls from Kinshasa, Zaire, were identified and sought for serologic testing for evidence of HTLV-III/LAV infection. Twenty (9.8%) of 204 case-household members and three (1.9%) of 155 control-household members were HTLV-III/LAV seropositive (relative risk=5.1; 95% confidence interval, 1.7 to 15.2). Eleven (61.1%) of 18 spouses of patients with AIDS were HTLV-III/LAV seropositive, compared with one (3.7%) of 27 control spouses (relative risk=16.5; 95% confidence interval, 3.7 to 75.0). Except for spouses, the rate of HTLV-III/LAV seropositivity did not differ significantly between case and control households. Furthermore, for adults in case households who were not spouses, the number seropositive for HTLV-III/LAV was identical to that predicted from sex- and age-specific HTLV-III/LAV seroprevalence rates. These data from Zaire confirm the results of US and European studies of household contacts of infected hemophiliacs and pediatric patients with AIDS.

Original languageEnglish (US)
Pages (from-to)721-724
Number of pages4
JournalJAMA: The Journal of the American Medical Association
Volume256
Issue number6
DOIs
StatePublished - Aug 8 1986
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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