Prevalence of hepatitis C virus infection in urban children

Research output: Contribution to journalArticle

Abstract

Objectives: To determine the prevalence of hepatitis C virus (HCV) infection in children with an unknown or negative human immunodeficiency virus (HIV) status attending an urban hospital pediatric primary care clinic, and to identify HCV risk factors in their mothers. Study design: This was a cross-sectional study of 1034 children tested for HCV antibodies (anti-HCV) after excluding children known to be HIV-positive. We assessed maternal HCV risk factors through structured interviews with a sample of mothers (n = 573) and through review of available medical records (n = 347) for a subsample of mother-child pairs. Means, proportions, and 95% confidence intervals were used to estimate the prevalence of anti-HCV and maternal risk factors. Results: One child (0.1%; 95% CI, 0.002, 0.5) was anti-HCV positive. History of blood transfusion was reported by 7% of mothers and intravenous drug use (IVDU) by 1.8%. A subsample of mothers significantly underreported IVDU when compared with medical record review (1.5% vs 7.8%, P <.001). Conclusions: Our findings suggest that universal screening of children for HCV in high-risk urban communities is not warranted. However, self-report may not be reliable for identifying mothers with a history of IVDU, for whom HCV testing is recommended.

Original languageEnglish (US)
Pages (from-to)54-59
Number of pages6
JournalJournal of Pediatrics
Volume143
Issue number1
DOIs
StatePublished - Jul 1 2003

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Virus Diseases
Hepacivirus
Mothers
Hepatitis C Antibodies
Medical Records
HIV
Pharmaceutical Preparations
Urban Hospitals
Blood Transfusion
Self Report
Primary Health Care
Cross-Sectional Studies
Confidence Intervals
Interviews
Pediatrics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Prevalence of hepatitis C virus infection in urban children. / El-Kamary, Samer S.; Serwint, Janet Rose; Joffe, Alain; Santosham, Mathuram; Duggan, Anne K.

In: Journal of Pediatrics, Vol. 143, No. 1, 01.07.2003, p. 54-59.

Research output: Contribution to journalArticle

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