Prevalence of dysglycemia and clinical presentation of pulmonary tuberculosis in Western India

Vidya Mave, S. Meshram, R. Lokhande, D. Kadam, S. Dharmshale, R. Bharadwaj, A. Kagal, N. Pradhan, S. Deshmukh, S. Atre, T. Sahasrabudhe, M. Barthwal, S. Meshram, A. Kakrani, V. Kulkarni, S. Raskar, Nishi Suryavanshi, R. Shivakoti, S. Chon, Elizabeth Selvin & 4 others A. Gupte, Amita Gupta, Nikhil Gupte, Jonathan E Golub

Research output: Contribution to journalArticle

Abstract

SETTING: Pune, India. OBJECTIVES: To estimate the prevalence and risk factors of pre-diabetes mellitus (DM) and DM, and its associations with the clinical presentation of tuberculosis (TB). DESIGN: Screening for DM was conducted among adults (age 7 18 years) with confirmed TB between December 2013 and January 2017. We used multinomial regression to evaluate the risk factors for pre-DM (glycated hemoglobin [HbA1c] 7 5.7–6.5% or fasting glucose 100–125 mg/dl) and DM (HbA1c 7 6.5% or fasting glucose 7 126 mg/dl or random blood glucose . 200 mg/dl or self-reported DM history/treatment) and the association of dysglycemia with the severity of TB disease. RESULTS: Among 1793 participants screened, 890 (50%) had microbiologically confirmed TB. Of these, 33% had pre-DM and 18% had DM; 41% were newly diagnosed. The median HbA1c level among newly diagnosed DM was 7.0% vs. 10.3% among known DM (P, 0.001). DM (adjusted OR [aOR] 4.94, 95%CI 2.33–10.48) and each per cent increase in HbA1c (aOR 1.42, 95%CI 1.01–2.01) was associated with .1þsmear grade or 69 days to TB detection. CONCLUSION: Over half of newly diagnosed TB patients had DM or pre-DM. DM and increasing dysglycemia was associated with higher bacterial burden at TB diagnosis, potentially indicating a higher risk of TB transmission to close contacts.

Original languageEnglish (US)
Pages (from-to)1280-1287
Number of pages8
JournalInternational Journal of Tuberculosis and Lung Disease
Volume21
Issue number12
DOIs
StatePublished - Dec 1 2017

Fingerprint

Pulmonary Tuberculosis
India
Diabetes Mellitus
Tuberculosis
Fasting
Glucose
Glycosylated Hemoglobin A
Blood Glucose

Keywords

  • Clinical presentation
  • Diabetes mellitus
  • India
  • Pre-diabetes mellitus
  • Risk factors
  • TB

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Prevalence of dysglycemia and clinical presentation of pulmonary tuberculosis in Western India. / Mave, Vidya; Meshram, S.; Lokhande, R.; Kadam, D.; Dharmshale, S.; Bharadwaj, R.; Kagal, A.; Pradhan, N.; Deshmukh, S.; Atre, S.; Sahasrabudhe, T.; Barthwal, M.; Meshram, S.; Kakrani, A.; Kulkarni, V.; Raskar, S.; Suryavanshi, Nishi; Shivakoti, R.; Chon, S.; Selvin, Elizabeth; Gupte, A.; Gupta, Amita; Gupte, Nikhil; Golub, Jonathan E.

In: International Journal of Tuberculosis and Lung Disease, Vol. 21, No. 12, 01.12.2017, p. 1280-1287.

Research output: Contribution to journalArticle

Mave, V, Meshram, S, Lokhande, R, Kadam, D, Dharmshale, S, Bharadwaj, R, Kagal, A, Pradhan, N, Deshmukh, S, Atre, S, Sahasrabudhe, T, Barthwal, M, Meshram, S, Kakrani, A, Kulkarni, V, Raskar, S, Suryavanshi, N, Shivakoti, R, Chon, S, Selvin, E, Gupte, A, Gupta, A, Gupte, N & Golub, JE 2017, 'Prevalence of dysglycemia and clinical presentation of pulmonary tuberculosis in Western India', International Journal of Tuberculosis and Lung Disease, vol. 21, no. 12, pp. 1280-1287. https://doi.org/10.5588/ijtld.17.0474
Mave, Vidya ; Meshram, S. ; Lokhande, R. ; Kadam, D. ; Dharmshale, S. ; Bharadwaj, R. ; Kagal, A. ; Pradhan, N. ; Deshmukh, S. ; Atre, S. ; Sahasrabudhe, T. ; Barthwal, M. ; Meshram, S. ; Kakrani, A. ; Kulkarni, V. ; Raskar, S. ; Suryavanshi, Nishi ; Shivakoti, R. ; Chon, S. ; Selvin, Elizabeth ; Gupte, A. ; Gupta, Amita ; Gupte, Nikhil ; Golub, Jonathan E. / Prevalence of dysglycemia and clinical presentation of pulmonary tuberculosis in Western India. In: International Journal of Tuberculosis and Lung Disease. 2017 ; Vol. 21, No. 12. pp. 1280-1287.
@article{c227198b296d4d48b60df2a3c988f7c4,
title = "Prevalence of dysglycemia and clinical presentation of pulmonary tuberculosis in Western India",
abstract = "SETTING: Pune, India. OBJECTIVES: To estimate the prevalence and risk factors of pre-diabetes mellitus (DM) and DM, and its associations with the clinical presentation of tuberculosis (TB). DESIGN: Screening for DM was conducted among adults (age 7 18 years) with confirmed TB between December 2013 and January 2017. We used multinomial regression to evaluate the risk factors for pre-DM (glycated hemoglobin [HbA1c] 7 5.7–6.5{\%} or fasting glucose 100–125 mg/dl) and DM (HbA1c 7 6.5{\%} or fasting glucose 7 126 mg/dl or random blood glucose . 200 mg/dl or self-reported DM history/treatment) and the association of dysglycemia with the severity of TB disease. RESULTS: Among 1793 participants screened, 890 (50{\%}) had microbiologically confirmed TB. Of these, 33{\%} had pre-DM and 18{\%} had DM; 41{\%} were newly diagnosed. The median HbA1c level among newly diagnosed DM was 7.0{\%} vs. 10.3{\%} among known DM (P, 0.001). DM (adjusted OR [aOR] 4.94, 95{\%}CI 2.33–10.48) and each per cent increase in HbA1c (aOR 1.42, 95{\%}CI 1.01–2.01) was associated with .1{\th}smear grade or 69 days to TB detection. CONCLUSION: Over half of newly diagnosed TB patients had DM or pre-DM. DM and increasing dysglycemia was associated with higher bacterial burden at TB diagnosis, potentially indicating a higher risk of TB transmission to close contacts.",
keywords = "Clinical presentation, Diabetes mellitus, India, Pre-diabetes mellitus, Risk factors, TB",
author = "Vidya Mave and S. Meshram and R. Lokhande and D. Kadam and S. Dharmshale and R. Bharadwaj and A. Kagal and N. Pradhan and S. Deshmukh and S. Atre and T. Sahasrabudhe and M. Barthwal and S. Meshram and A. Kakrani and V. Kulkarni and S. Raskar and Nishi Suryavanshi and R. Shivakoti and S. Chon and Elizabeth Selvin and A. Gupte and Amita Gupta and Nikhil Gupte and Golub, {Jonathan E}",
year = "2017",
month = "12",
day = "1",
doi = "10.5588/ijtld.17.0474",
language = "English (US)",
volume = "21",
pages = "1280--1287",
journal = "International Journal of Tuberculosis and Lung Disease",
issn = "1027-3719",
publisher = "International Union against Tubercul. and Lung Dis.",
number = "12",

}

TY - JOUR

T1 - Prevalence of dysglycemia and clinical presentation of pulmonary tuberculosis in Western India

AU - Mave, Vidya

AU - Meshram, S.

AU - Lokhande, R.

AU - Kadam, D.

AU - Dharmshale, S.

AU - Bharadwaj, R.

AU - Kagal, A.

AU - Pradhan, N.

AU - Deshmukh, S.

AU - Atre, S.

AU - Sahasrabudhe, T.

AU - Barthwal, M.

AU - Meshram, S.

AU - Kakrani, A.

AU - Kulkarni, V.

AU - Raskar, S.

AU - Suryavanshi, Nishi

AU - Shivakoti, R.

AU - Chon, S.

AU - Selvin, Elizabeth

AU - Gupte, A.

AU - Gupta, Amita

AU - Gupte, Nikhil

AU - Golub, Jonathan E

PY - 2017/12/1

Y1 - 2017/12/1

N2 - SETTING: Pune, India. OBJECTIVES: To estimate the prevalence and risk factors of pre-diabetes mellitus (DM) and DM, and its associations with the clinical presentation of tuberculosis (TB). DESIGN: Screening for DM was conducted among adults (age 7 18 years) with confirmed TB between December 2013 and January 2017. We used multinomial regression to evaluate the risk factors for pre-DM (glycated hemoglobin [HbA1c] 7 5.7–6.5% or fasting glucose 100–125 mg/dl) and DM (HbA1c 7 6.5% or fasting glucose 7 126 mg/dl or random blood glucose . 200 mg/dl or self-reported DM history/treatment) and the association of dysglycemia with the severity of TB disease. RESULTS: Among 1793 participants screened, 890 (50%) had microbiologically confirmed TB. Of these, 33% had pre-DM and 18% had DM; 41% were newly diagnosed. The median HbA1c level among newly diagnosed DM was 7.0% vs. 10.3% among known DM (P, 0.001). DM (adjusted OR [aOR] 4.94, 95%CI 2.33–10.48) and each per cent increase in HbA1c (aOR 1.42, 95%CI 1.01–2.01) was associated with .1þsmear grade or 69 days to TB detection. CONCLUSION: Over half of newly diagnosed TB patients had DM or pre-DM. DM and increasing dysglycemia was associated with higher bacterial burden at TB diagnosis, potentially indicating a higher risk of TB transmission to close contacts.

AB - SETTING: Pune, India. OBJECTIVES: To estimate the prevalence and risk factors of pre-diabetes mellitus (DM) and DM, and its associations with the clinical presentation of tuberculosis (TB). DESIGN: Screening for DM was conducted among adults (age 7 18 years) with confirmed TB between December 2013 and January 2017. We used multinomial regression to evaluate the risk factors for pre-DM (glycated hemoglobin [HbA1c] 7 5.7–6.5% or fasting glucose 100–125 mg/dl) and DM (HbA1c 7 6.5% or fasting glucose 7 126 mg/dl or random blood glucose . 200 mg/dl or self-reported DM history/treatment) and the association of dysglycemia with the severity of TB disease. RESULTS: Among 1793 participants screened, 890 (50%) had microbiologically confirmed TB. Of these, 33% had pre-DM and 18% had DM; 41% were newly diagnosed. The median HbA1c level among newly diagnosed DM was 7.0% vs. 10.3% among known DM (P, 0.001). DM (adjusted OR [aOR] 4.94, 95%CI 2.33–10.48) and each per cent increase in HbA1c (aOR 1.42, 95%CI 1.01–2.01) was associated with .1þsmear grade or 69 days to TB detection. CONCLUSION: Over half of newly diagnosed TB patients had DM or pre-DM. DM and increasing dysglycemia was associated with higher bacterial burden at TB diagnosis, potentially indicating a higher risk of TB transmission to close contacts.

KW - Clinical presentation

KW - Diabetes mellitus

KW - India

KW - Pre-diabetes mellitus

KW - Risk factors

KW - TB

UR - http://www.scopus.com/inward/record.url?scp=85034844612&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85034844612&partnerID=8YFLogxK

U2 - 10.5588/ijtld.17.0474

DO - 10.5588/ijtld.17.0474

M3 - Article

VL - 21

SP - 1280

EP - 1287

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

SN - 1027-3719

IS - 12

ER -