Prevalence of depression and its related factors among Chinese women with breast cancer

Xiaoli Chen, Ying Zheng, Wei Zheng, Kai Gu, Zhi Chen, Wei Lu, Xiao Ou Shu

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


Background. Little information is available regarding depression among Asian breast cancer survivors. Methods. We estimated the prevalence of depression and its correlates among 1400 participants of a population-based cohort study of women with stage 0IV breast cancer in Shanghai, China. Through in-person interviews conducted at 6 months and 18 months post-diagnosis and review of medical charts, information on sociodemographic and clinical factors and quality of life (QOL) was collected. Depression was measured by the 20-item Center for Epidemiologic Studies Depression Scale at 18 months post-diagnosis. Results. Approximately 26% of participants had mild to severe depression and 13% fulfilled the criteria of clinical depression at 18 months post-diagnosis. Women with lower income were more likely to have depression than women with higher income (prevalence: 16.6% vs. 6.9% for mild depression and 17.1% vs. 5.5% for clinical depression, respectively). Depression was more common among women who were widowed (18.9%) or divorced/separated/single (16.4%) than among women who were married (11.8%). Women with comorbidity were more likely to have clinical depression (17.3% vs 11.2%). Multivariate analysis showed that low income, marital status, comorbidity, and low QOL scores were independent predictors for depression. We did not find that prevalence of depression differed by menopausal status, estrogen or progesterone receptor status, disease stage, or cancer-related treatments. Conclusion. Depression is common among Asian women with breast cancer. Routine screening and prevention of depression are warranted among women with breast cancer.

Original languageEnglish (US)
Pages (from-to)1128-1136
Number of pages9
JournalActa Oncologica
Issue number8
StatePublished - 2009
Externally publishedYes


  • Breast cancer
  • Depression
  • Prevalence
  • Risk factor

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging


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