TY - JOUR
T1 - Prevalence of cryoglobulinemia in hepatitis C virus (HCV) positive patients with and without human immunodeficiency virus (HIV) coinfection
AU - Dezzutti, Charlene S.
AU - Astemborski, Jacquie
AU - Thomas, David L.
AU - Marshall, James H.
AU - Cabrera, Thania
AU - Purdy, Michael
AU - Vlahov, David
AU - Garfein, Richard S.
PY - 2004/11
Y1 - 2004/11
N2 - Background: Coinfection with human immunodeficiency virus (HIV) has been shown to influence the natural history of hepatitis C infection. Objective: Our interest was to determine if HIV coinfection influences the prevalence of cryoglobulinemia in hepatitis C virus (HCV) infected persons. Study design: A total of 384 HCV RNA positive (234 HIV-infected and 150 HIV-uninfected) participants were tested at two visits, 18 months apart, for HCV and HIV RNA, CD4, and liver enzyme levels. Serum cryoglobulin levels were measured at a subsequent visit for a subset of the sample. Results: HIV-infected participants had significantly higher HCV RNA levels (P < 0.0001) and aspartate transaminase (AST) levels (P < 0.0001), but not alanine transaminase (ALT) levels (P > 0.05) as compared with HIV-uninfected participants. These findings were consistent at both visits and no significant changes were observed between visits. Fifty (19%) of the 264 participants tested had detectable cryoglobulins. No difference was observed in HIV seropositivity among participants with or without cryoglobulinemia (68% versus 61%; odds ratio = 1.34, P = 0.37). However, among HIV coinfected participants, elevated AST levels (P = 0.04) and lower CD4 levels (P = 0.02) were associated with cryoglobulinemia. Conclusions: While previously reported associations were found between HIV and coinfection with HCV in this study, we did not find an association between HIV infection and cryoglobulinemia.
AB - Background: Coinfection with human immunodeficiency virus (HIV) has been shown to influence the natural history of hepatitis C infection. Objective: Our interest was to determine if HIV coinfection influences the prevalence of cryoglobulinemia in hepatitis C virus (HCV) infected persons. Study design: A total of 384 HCV RNA positive (234 HIV-infected and 150 HIV-uninfected) participants were tested at two visits, 18 months apart, for HCV and HIV RNA, CD4, and liver enzyme levels. Serum cryoglobulin levels were measured at a subsequent visit for a subset of the sample. Results: HIV-infected participants had significantly higher HCV RNA levels (P < 0.0001) and aspartate transaminase (AST) levels (P < 0.0001), but not alanine transaminase (ALT) levels (P > 0.05) as compared with HIV-uninfected participants. These findings were consistent at both visits and no significant changes were observed between visits. Fifty (19%) of the 264 participants tested had detectable cryoglobulins. No difference was observed in HIV seropositivity among participants with or without cryoglobulinemia (68% versus 61%; odds ratio = 1.34, P = 0.37). However, among HIV coinfected participants, elevated AST levels (P = 0.04) and lower CD4 levels (P = 0.02) were associated with cryoglobulinemia. Conclusions: While previously reported associations were found between HIV and coinfection with HCV in this study, we did not find an association between HIV infection and cryoglobulinemia.
KW - ALT
KW - AST
KW - Coinfection
KW - Cryoglobulinemia
KW - HAART
KW - HCV
KW - HIV
KW - Human immunodeficiency virus
KW - alanine transaminase
KW - aspartate transaminase
KW - hepatitis C Virus
KW - highly active antiretroviral therapy
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U2 - 10.1016/j.jcv.2004.03.014
DO - 10.1016/j.jcv.2004.03.014
M3 - Article
C2 - 15465414
AN - SCOPUS:4744372000
SN - 1386-6532
VL - 31
SP - 210
EP - 214
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
IS - 3
ER -