Prevalence of chronic hepatitis B and status of HBV care among rural women who planned to conceive in China

Yuanyuan Wang; Hong Zhou; Long Zhang; Qiuyue Zhong; Qiaomei Wang; Haiping Shen; Man Zhang; Yanjie Huang; Anqi Wang; Kenrad Nelson; Yiping Zhang; Donghai Yan; Zuoqi Peng; Ya Zhang; Xiaona Xin; Hongguang Zhang; Jun Zhao; Ying Yang; Yuan He; Jihong Xu; Yan Wang; Xiaoli Liu; Yan Wang; Xu Ma

doi:10.1038/s41598-017-12005-2

Prevalence of chronic hepatitis B and status of HBV care among rural women who planned to conceive in China

Yuanyuan Wang, Hong Zhou, Long Zhang, Qiuyue Zhong, Qiaomei Wang, Haiping Shen, Man Zhang, Yanjie Huang, Anqi Wang, Kenrad Nelson, Yiping Zhang, Donghai Yan, Zuoqi Peng, Ya Zhang, Xiaona Xin, Hongguang Zhang, Jun Zhao, Ying Yang, Yuan He, Jihong XuYan Wang, Xiaoli Liu, Yan Wang, Xu Ma

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Globally, one third of prevalent chronic hepatitis B (CHB) virus infection (HBV) occurred in China. Assessing the prevalence of CHB infesction and status of HBV-related services among pre-conception women will provide insight into risks of mother to child transmission (MTCT). A cross-sectional analysis of data from the National Free Pre-pregnancy Checkups (NFPC) program in 2010-2014 was conducted. A standardized questionnaire which collected demographic information and enzyme-linked immunosorbent assays (ELISA) which tested serological HBV markers were applied. A total of 16,051,850 rural women aged 15-49 years were included. 5.2% of women were infected with CHB, among whom, 28.6% were also hepatitis B e antigen (HBeAg) positive. The most CHB concentrated places were distributed in southeastern coastal provinces. Women born after 1992 did not experience a higher level of vaccine-induced immunity compared to those born before 1992. Nine in ten rural women with CHB were not aware of their HBV status and a very small proportion of women (0.22%) had received antiviral treatment. Our data demonstrated an overall high-intermediate burden of CHB. Heterogeneity of geographic distribution, high proportion of HBeAg, insufficient awareness of HBV status, and low access to HBV treatment are challenges for preventing the MTCT.

Original language	English (US)
Article number	12090
Journal	Scientific reports
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s41598-017-12005-2
State	Published - Dec 1 2017

ASJC Scopus subject areas

General

Access to Document

10.1038/s41598-017-12005-2

Cite this

Wang, Y., Zhou, H., Zhang, L., Zhong, Q., Wang, Q., Shen, H., Zhang, M., Huang, Y., Wang, A., Nelson, K., Zhang, Y., Yan, D., Peng, Z., Zhang, Y., Xin, X., Zhang, H., Zhao, J., Yang, Y., He, Y., ... Ma, X. (2017). Prevalence of chronic hepatitis B and status of HBV care among rural women who planned to conceive in China. Scientific reports, 7(1), Article 12090. https://doi.org/10.1038/s41598-017-12005-2

Wang, Y, Zhou, H, Zhang, L, Zhong, Q, Wang, Q, Shen, H, Zhang, M, Huang, Y, Wang, A, Nelson, K, Zhang, Y, Yan, D, Peng, Z, Zhang, Y, Xin, X, Zhang, H, Zhao, J, Yang, Y, He, Y, Xu, J, Wang, Y, Liu, X, Wang, Y & Ma, X 2017, 'Prevalence of chronic hepatitis B and status of HBV care among rural women who planned to conceive in China', Scientific reports, vol. 7, no. 1, 12090. https://doi.org/10.1038/s41598-017-12005-2

@article{691ad5ea3c1d46f9bd04609b405570a5,

title = "Prevalence of chronic hepatitis B and status of HBV care among rural women who planned to conceive in China",

abstract = "Globally, one third of prevalent chronic hepatitis B (CHB) virus infection (HBV) occurred in China. Assessing the prevalence of CHB infesction and status of HBV-related services among pre-conception women will provide insight into risks of mother to child transmission (MTCT). A cross-sectional analysis of data from the National Free Pre-pregnancy Checkups (NFPC) program in 2010-2014 was conducted. A standardized questionnaire which collected demographic information and enzyme-linked immunosorbent assays (ELISA) which tested serological HBV markers were applied. A total of 16,051,850 rural women aged 15-49 years were included. 5.2% of women were infected with CHB, among whom, 28.6% were also hepatitis B e antigen (HBeAg) positive. The most CHB concentrated places were distributed in southeastern coastal provinces. Women born after 1992 did not experience a higher level of vaccine-induced immunity compared to those born before 1992. Nine in ten rural women with CHB were not aware of their HBV status and a very small proportion of women (0.22%) had received antiviral treatment. Our data demonstrated an overall high-intermediate burden of CHB. Heterogeneity of geographic distribution, high proportion of HBeAg, insufficient awareness of HBV status, and low access to HBV treatment are challenges for preventing the MTCT.",

author = "Yuanyuan Wang and Hong Zhou and Long Zhang and Qiuyue Zhong and Qiaomei Wang and Haiping Shen and Man Zhang and Yanjie Huang and Anqi Wang and Kenrad Nelson and Yiping Zhang and Donghai Yan and Zuoqi Peng and Ya Zhang and Xiaona Xin and Hongguang Zhang and Jun Zhao and Ying Yang and Yuan He and Jihong Xu and Yan Wang and Xiaoli Liu and Yan Wang and Xu Ma",

note = "Funding Information: We thank health workers and countless participants throughout 31 provinces in NFPC for great efforts and collaboration. This study was supported by National Key Research and Development Program (No. 2016YFC1000307 and No. 2016YFC1000300) from Ministry of science and technology of the people{\textquoteright}s republic of China. Publisher Copyright: {\textcopyright} 2017 The Author(s).",

year = "2017",

month = dec,

day = "1",

doi = "10.1038/s41598-017-12005-2",

language = "English (US)",

volume = "7",

journal = "Scientific reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - Prevalence of chronic hepatitis B and status of HBV care among rural women who planned to conceive in China

AU - Wang, Yuanyuan

AU - Zhou, Hong

AU - Zhang, Long

AU - Zhong, Qiuyue

AU - Wang, Qiaomei

AU - Shen, Haiping

AU - Zhang, Man

AU - Huang, Yanjie

AU - Wang, Anqi

AU - Nelson, Kenrad

AU - Zhang, Yiping

AU - Yan, Donghai

AU - Peng, Zuoqi

AU - Zhang, Ya

AU - Xin, Xiaona

AU - Zhang, Hongguang

AU - Zhao, Jun

AU - Yang, Ying

AU - He, Yuan

AU - Xu, Jihong

AU - Wang, Yan

AU - Liu, Xiaoli

AU - Wang, Yan

AU - Ma, Xu

N1 - Funding Information: We thank health workers and countless participants throughout 31 provinces in NFPC for great efforts and collaboration. This study was supported by National Key Research and Development Program (No. 2016YFC1000307 and No. 2016YFC1000300) from Ministry of science and technology of the people’s republic of China. Publisher Copyright: © 2017 The Author(s).

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Globally, one third of prevalent chronic hepatitis B (CHB) virus infection (HBV) occurred in China. Assessing the prevalence of CHB infesction and status of HBV-related services among pre-conception women will provide insight into risks of mother to child transmission (MTCT). A cross-sectional analysis of data from the National Free Pre-pregnancy Checkups (NFPC) program in 2010-2014 was conducted. A standardized questionnaire which collected demographic information and enzyme-linked immunosorbent assays (ELISA) which tested serological HBV markers were applied. A total of 16,051,850 rural women aged 15-49 years were included. 5.2% of women were infected with CHB, among whom, 28.6% were also hepatitis B e antigen (HBeAg) positive. The most CHB concentrated places were distributed in southeastern coastal provinces. Women born after 1992 did not experience a higher level of vaccine-induced immunity compared to those born before 1992. Nine in ten rural women with CHB were not aware of their HBV status and a very small proportion of women (0.22%) had received antiviral treatment. Our data demonstrated an overall high-intermediate burden of CHB. Heterogeneity of geographic distribution, high proportion of HBeAg, insufficient awareness of HBV status, and low access to HBV treatment are challenges for preventing the MTCT.

AB - Globally, one third of prevalent chronic hepatitis B (CHB) virus infection (HBV) occurred in China. Assessing the prevalence of CHB infesction and status of HBV-related services among pre-conception women will provide insight into risks of mother to child transmission (MTCT). A cross-sectional analysis of data from the National Free Pre-pregnancy Checkups (NFPC) program in 2010-2014 was conducted. A standardized questionnaire which collected demographic information and enzyme-linked immunosorbent assays (ELISA) which tested serological HBV markers were applied. A total of 16,051,850 rural women aged 15-49 years were included. 5.2% of women were infected with CHB, among whom, 28.6% were also hepatitis B e antigen (HBeAg) positive. The most CHB concentrated places were distributed in southeastern coastal provinces. Women born after 1992 did not experience a higher level of vaccine-induced immunity compared to those born before 1992. Nine in ten rural women with CHB were not aware of their HBV status and a very small proportion of women (0.22%) had received antiviral treatment. Our data demonstrated an overall high-intermediate burden of CHB. Heterogeneity of geographic distribution, high proportion of HBeAg, insufficient awareness of HBV status, and low access to HBV treatment are challenges for preventing the MTCT.

UR - http://www.scopus.com/inward/record.url?scp=85029858490&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029858490&partnerID=8YFLogxK

U2 - 10.1038/s41598-017-12005-2

DO - 10.1038/s41598-017-12005-2

M3 - Article

C2 - 28935971

AN - SCOPUS:85029858490

SN - 2045-2322

VL - 7

JO - Scientific reports

JF - Scientific reports

IS - 1

M1 - 12090

ER -

Prevalence of chronic hepatitis B and status of HBV care among rural women who planned to conceive in China

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this